SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 ASP A 995
TYR A1015
ARG A 933
TYR A1016
None
1.26A 1cebA-3n23A:
undetectable
1cebA-3n23A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 ASP A 995
TYR A1015
ARG A 933
TYR A1016
None
1.25A 1cebB-3n23A:
undetectable
1cebB-3n23A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 GLY A 709
ASP A 714
GLY A 213
SER A 368
PHD  A 369 ( 3.5A)
PHD  A 369 ( 2.9A)
PHD  A 369 ( 2.8A)
PHD  A 369 ( 2.6A)
0.79A 1eswA-3n23A:
undetectable
1eswA-3n23A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 ILE B  41
GLY B  44
CYH B  45
LEU A 856
TYR A 987
None
1.48A 1fm6X-3n23B:
undetectable
1fm6X-3n23B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 ILE B  41
GLY B  44
CYH B  45
LEU A 990
LEU A 856
None
1.33A 1fm6X-3n23B:
undetectable
1fm6X-3n23B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 ILE B  41
PHE B  42
GLY B  44
CYH B  45
LEU A 856
None
0.96A 1fm6X-3n23B:
undetectable
1fm6X-3n23B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 VAL A 252
GLY A 181
THR A  50
ILE A 250
None
0.76A 1gtnC-3n23A:
undetectable
1gtnD-3n23A:
undetectable
1gtnC-3n23A:
6.15
1gtnD-3n23A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 GLY A 502
ASN A 476
MET A 500
ILE A 507
LEU A 576
None
1.28A 1lhuA-3n23A:
undetectable
1lhuA-3n23A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 4 LEU A 330
VAL A 333
CYH A 336
ALA A 816
None
1.29A 1mz9E-3n23A:
undetectable
1mz9E-3n23A:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 TYR A 771
ILE A 919
PRO A 778
GLU A 779
None
1.35A 1oniA-3n23A:
undetectable
1oniC-3n23A:
undetectable
1oniA-3n23A:
8.50
1oniC-3n23A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 PRO A  76
GLY A  69
ASN A  71
ARG A 257
VAL A 734
None
1.12A 1r30A-3n23A:
undetectable
1r30A-3n23A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 PRO A  76
GLY A  69
ASN A  71
ARG A 257
VAL A 734
None
1.12A 1r30B-3n23A:
undetectable
1r30B-3n23A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 4 SER A 200
ILE A 199
VAL A 184
THR A 240
None
1.10A 1u70A-3n23A:
undetectable
1u70A-3n23A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 THR A 913
CYH A 802
LEU A 961
MET A 967
None
1.47A 1uw6A-3n23A:
undetectable
1uw6B-3n23A:
undetectable
1uw6A-3n23A:
12.27
1uw6B-3n23A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 THR A 913
CYH A 802
LEU A 961
MET A 967
None
1.47A 1uw6D-3n23A:
undetectable
1uw6E-3n23A:
undetectable
1uw6D-3n23A:
12.27
1uw6E-3n23A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 THR A 913
CYH A 802
LEU A 961
MET A 967
None
1.46A 1uw6G-3n23A:
undetectable
1uw6H-3n23A:
undetectable
1uw6G-3n23A:
12.27
1uw6H-3n23A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 THR A 913
CYH A 802
LEU A 961
MET A 967
None
1.41A 1uw6P-3n23A:
undetectable
1uw6Q-3n23A:
undetectable
1uw6P-3n23A:
12.27
1uw6Q-3n23A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 LEU A 961
MET A 967
THR A 913
CYH A 802
None
1.46A 1uw6P-3n23A:
undetectable
1uw6T-3n23A:
undetectable
1uw6P-3n23A:
12.27
1uw6T-3n23A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
5 / 12 THR A 900
ILE B 283
GLY B 284
SER B 286
GLU B 281
None
1.02A 1vq1B-3n23A:
undetectable
1vq1B-3n23A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 11 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.89A 1z11A-3n23B:
undetectable
1z11A-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 11 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.91A 1z11B-3n23B:
undetectable
1z11B-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 10 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.88A 1z11C-3n23B:
undetectable
1z11C-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 10 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.91A 1z11D-3n23B:
undetectable
1z11D-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 GLY A 261
THR A 265
MET A 260
SER A 715
None
1.23A 2o5yH-3n23A:
undetectable
2o5yL-3n23A:
undetectable
2o5yH-3n23A:
13.00
2o5yL-3n23A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 GLY A 709
ASP A 714
SER A 718
PHD  A 369 ( 3.5A)
PHD  A 369 ( 2.9A)
None
0.71A 2qhfA-3n23A:
undetectable
2qhfA-3n23A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 TYR A 253
VAL A 252
TYR A  48
ASP A  35
None
1.27A 2x45A-3n23A:
undetectable
2x45A-3n23A:
10.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 10 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 (-3.7A)
0.74A 3a3yA-3n23A:
55.3
3a3yA-3n23A:
85.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 10 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 786
LEU A 793
THR A 797
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
0.48A 3a3yA-3n23A:
55.3
3a3yA-3n23A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 THR A 219
SER A 477
LYS A 480
None
1.10A 3aocC-3n23A:
4.1
3aocC-3n23A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 TYR A 253
VAL A 252
TYR A  48
ASP A  35
None
1.25A 3bu1A-3n23A:
undetectable
3bu1A-3n23A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 GLY A 255
GLY A 261
MET A 260
ASN A  71
None
1.10A 3e9rA-3n23A:
undetectable
3e9rA-3n23A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 GLY A 255
GLY A 261
MET A 260
ASN A  71
None
1.07A 3e9rC-3n23A:
undetectable
3e9rC-3n23A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 4 PRO A 588
THR A 375
GLY A 611
THR A 686
None
None
PHD  A 369 ( 4.5A)
None
1.11A 3ib1A-3n23A:
undetectable
3ib1A-3n23A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 TYR B 112
LEU B 153
GLY B 231
ILE B 178
ILE B  80
None
1.00A 3ijdA-3n23B:
undetectable
3ijdA-3n23B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 TYR B 112
LEU B 153
GLY B 231
ILE B 178
ILE B  80
None
1.07A 3ijdB-3n23B:
undetectable
3ijdB-3n23B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 ASN A 713
ASP A 710
ARG A 544
PHD  A 369 ( 3.6A)
MG  A1017 (-3.2A)
None
0.93A 3k13C-3n23A:
undetectable
3k13C-3n23A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 SER A 732
GLY A 731
SER A 210
ASN A 377
None
0.96A 3lslA-3n23A:
undetectable
3lslD-3n23A:
undetectable
3lslA-3n23A:
13.10
3lslD-3n23A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 GLY A 372
THR A 373
LEU A 374
ASP A 586
PHD  A 369 ( 4.9A)
PHD  A 369 ( 3.3A)
PHD  A 369 ( 3.9A)
None
0.98A 3ps9A-3n23A:
undetectable
3ps9A-3n23A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 11 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.94A 3t3rA-3n23B:
undetectable
3t3rA-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 5 ILE A 582
ALA A 448
HIS A 383
MET A 584
None
1.29A 4ac9B-3n23A:
2.9
4ac9C-3n23A:
2.5
4ac9B-3n23A:
20.56
4ac9C-3n23A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 5 ILE A 582
ALA A 448
HIS A 383
MET A 584
None
1.32A 4acaB-3n23A:
2.5
4acaC-3n23A:
2.7
4acaB-3n23A:
20.56
4acaC-3n23A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 TYR A 974
MET A 973
ILE A 800
None
None
OBN  A   1 ( 4.7A)
0.79A 4c8bB-3n23A:
undetectable
4c8bB-3n23A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
4 / 6 GLY B 237
PRO B 210
GLY B 280
TYR B 279
None
0.77A 4dxuA-3n23B:
undetectable
4dxuA-3n23B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 GLY A 539
ALA A 382
GLU A 543
GLN A 532
None
0.97A 4g0uA-3n23A:
undetectable
4g0uA-3n23A:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 GLN A 111
GLU A 312
PHE A 786
LEU A 793
ARG A 880
OBN  A   1 (-3.8A)
None
None
None
OBN  A   1 (-3.7A)
0.99A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
1.01A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
0.86A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
6 / 12 GLN A 111
GLU A 312
PHE A 783
PHE A 786
LEU A 793
ARG A 880
OBN  A   1 (-3.8A)
None
OBN  A   1 (-3.5A)
None
None
OBN  A   1 (-3.7A)
1.10A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
1.02A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
0.86A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 ILE A 761
GLY A 361
GLY A 758
ASP A 722
ARG A 827
None
1.16A 4iv0B-3n23A:
undetectable
4iv0B-3n23A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
4 / 7 TYR A 895
ASN B 141
GLU B  63
TYR B 139
None
1.29A 4mi4A-3n23A:
undetectable
4mi4C-3n23A:
undetectable
4mi4A-3n23A:
13.27
4mi4C-3n23A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 ASN A 776
LEU A 784
LEU A 795
ILE A 320
None
0.98A 4okwA-3n23A:
undetectable
4okwA-3n23A:
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
8 / 12 ASP A 121
LEU A 125
PHE A 316
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
OBN  A   1 (-3.4A)
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
0.92A 4retA-3n23A:
58.1
4retA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
PHE A 316
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
ARG A 880
None
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
OBN  A   1 (-3.7A)
0.94A 4retA-3n23A:
58.1
4retA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
7 / 12 ASP A 121
LEU A 125
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
OBN  A   1 (-3.4A)
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
0.96A 4retC-3n23A:
52.4
4retC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
8 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
OBN  A   1 (-3.7A)
0.97A 4retC-3n23A:
52.4
4retC-3n23A:
97.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 10 GLY A 950
GLU A 954
LEU A 815
ASP A 926
ALA A 925
None
1.26A 4wnuD-3n23A:
undetectable
4wnuD-3n23A:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 ASP A 121
LEU A 125
GLU A 312
GLY A 319
ALA A 323
GLU A 327
PHE A 786
ILE A 800
ASP A 884
OBN  A   1 (-3.4A)
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 ( 4.8A)
0.82A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 PRO A 118
ILE A 315
THR A 797
ARG A 880
OBN  A   1 (-3.6A)
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
1.05A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 PRO A 118
VAL A 322
PHE A 783
ARG A 880
OBN  A   1 (-3.6A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
OBN  A   1 (-3.7A)
1.18A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
4 / 7 LYS B 192
TYR B 279
LEU B 209
PHE B 238
None
1.04A 4yv5B-3n23B:
undetectable
4yv5B-3n23B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.12A 4zdyA-3n23B:
undetectable
4zdyA-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.13A 4ze2A-3n23B:
undetectable
4ze2A-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 ALA A 448
SER A 447
SER A 215
PRO A 587
None
1.04A 5c6pA-3n23A:
0.0
5c6pA-3n23A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.12A 5esgA-3n23B:
undetectable
5esgA-3n23B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 ALA A 424
LEU A 450
ILE A 390
GLY A 539
PHE A 548
None
1.23A 5eshA-3n23A:
undetectable
5eshA-3n23A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.13A 5eslA-3n23B:
undetectable
5eslA-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 ILE A 850
GLY A 851
PHE A 985
PHE A 860
None
0.95A 5hieD-3n23A:
undetectable
5hieD-3n23A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 VAL A 734
ASP A 733
ALA A 264
SER A 268
THR A 254
None
1.07A 5hnzB-3n23A:
2.5
5hnzB-3n23A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
4 / 6 TYR A1016
ILE A 991
TYR A 994
TYR B  39
None
1.27A 5igyA-3n23A:
undetectable
5igyA-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
4 / 6 TYR A1016
ILE A 991
TYR A 994
TYR B  39
None
1.24A 5ih0A-3n23A:
1.1
5ih0A-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
6 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
THR A 797
None
None
None
None
None
OBN  A   1 (-2.8A)
1.43A 5jlcA-3n23B:
undetectable
5jlcA-3n23B:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 GLN A 854
THR A 774
ASP A 926
None
0.92A 5k9dA-3n23A:
undetectable
5k9dA-3n23A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
3 / 3 GLN A 903
THR A 900
ASP B 289
None
0.93A 5k9dA-3n23A:
undetectable
5k9dA-3n23A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 VAL A 734
ASP A 733
ALA A 264
SER A 268
PRO A  76
None
1.26A 5nd2B-3n23A:
2.3
5nd2B-3n23A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 VAL A 734
ASP A 733
ALA A 264
SER A 268
THR A 254
None
0.99A 5nd3B-3n23A:
2.1
5nd3B-3n23A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.13A 5v5zA-3n23B:
undetectable
5v5zA-3n23B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 GLY A 542
ILE A 620
GLN A 376
ASP A 586
None
1.17A 5vlmC-3n23A:
undetectable
5vlmC-3n23A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 GLY A 625
LYS A 622
VAL A 755
GLY A 603
ILE A 604
None
1.10A 5vooB-3n23A:
2.2
5vooB-3n23A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 7 PHE A 860
ALA A 855
GLY A 857
THR A 781
None
0.81A 5ybbB-3n23A:
undetectable
5ybbB-3n23A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 ALA A 382
GLY A 539
ASP A 394
ALA A 393
PRO A 587
None
1.21A 5zvgA-3n23A:
undetectable
5zvgA-3n23A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 ALA A 382
GLY A 539
ASP A 394
ALA A 393
PRO A 587
None
1.21A 5zvgB-3n23A:
undetectable
5zvgB-3n23A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
5 / 12 ILE B  61
LEU A 990
VAL A 864
ALA A 867
LEU A 856
None
1.43A 6a7pB-3n23B:
undetectable
6a7pB-3n23B:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa;
Sus
scrofa)
5 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
None
1.11A 6e8qA-3n23B:
undetectable
6e8qA-3n23B:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 ALA A 621
GLY A 611
THR A 686
ILE A 694
None
PHD  A 369 ( 4.5A)
None
None
0.75A 6f8cA-3n23A:
0.8
6f8cA-3n23A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus
scrofa;
Sus
scrofa)
4 / 4 ALA A 956
ALA A 959
ALA G  34
ALA G  37
None
0.76A 6gtqA-3n23A:
0.0
6gtqB-3n23A:
0.0
6gtqA-3n23A:
10.46
6gtqB-3n23A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus
scrofa;
Sus
scrofa)
4 / 4 ALA G  34
ALA G  37
ALA A 956
ALA A 959
None
0.76A 6gtqA-3n23G:
undetectable
6gtqB-3n23G:
undetectable
6gtqA-3n23G:
12.80
6gtqB-3n23G:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 TYR A 847
ILE A 777
ALA A 323
VAL A 322
None
None
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
1.00A 6hu9a-3n23A:
1.9
6hu9e-3n23A:
0.3
6hu9a-3n23A:
19.48
6hu9e-3n23A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus
scrofa;
Sus
scrofa)
5 / 11 ASP B  70
TYR G  23
VAL G  26
GLY G  30
ALA G  37
None
1.36A 6hu9A-3n23B:
undetectable
6hu9E-3n23B:
undetectable
6hu9I-3n23B:
undetectable
6hu9A-3n23B:
21.32
6hu9E-3n23B:
19.71
6hu9I-3n23B:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus
scrofa;
Sus
scrofa)
5 / 10 ASP B  70
TYR G  23
VAL G  26
GLY G  30
ALA G  37
None
1.35A 6hu9L-3n23B:
undetectable
6hu9P-3n23B:
undetectable
6hu9T-3n23B:
undetectable
6hu9L-3n23B:
21.32
6hu9P-3n23B:
19.71
6hu9T-3n23B:
13.50