SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		3 / 3 THR A  36
GLU A  59
HIS A 283
 None
 0.91A 1xwfA-3n2xA:
undetectable		 1xwfA-3n2xA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		3 / 3 THR A  36
GLU A  59
HIS A 283
 None
 0.92A 1xwfB-3n2xA:
undetectable		 1xwfB-3n2xA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		3 / 3 THR A  36
GLU A  59
HIS A 283
 None
 0.89A 1xwfD-3n2xA:
undetectable		 1xwfD-3n2xA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 THR A 189
VAL A 199
ASP A 175
ILE A 173
 None
None
None
MCL  A 174 ( 3.6A)
 0.94A 2qbmA-3n2xA:
undetectable		 2qbmA-3n2xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 11 LEU A 306
LEU A 308
ILE A 255
ALA A 272
PHE A 225
 None
 1.16A 2qjuA-3n2xA:
undetectable		 2qjuA-3n2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QPU_B_QPSB3000_1
(ALPHA-AMYLASE TYPE A
ISOZYME)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 9 ASP A 110
VAL A  85
HIS A 103
ASP A  77
ALA A  72
 None
 1.38A 2qpuB-3n2xA:
6.7		 2qpuB-3n2xA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 5 PHE A 265
PHE A  52
PHE A 147
ILE A  71
 None
MCL  A 174 ( 4.8A)
None
None
 1.40A 2v0mD-3n2xA:
undetectable		 2v0mD-3n2xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 GLY A  55
ILE A 269
ASN A 224
GLU A  59
 MCL  A 174 ( 3.2A)
None
None
None
 0.84A 2x0pA-3n2xA:
undetectable		 2x0pA-3n2xA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
MCL  A 174 ( 3.2A)
None
None
 1.21A 2zifA-3n2xA:
undetectable		 2zifA-3n2xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
MCL  A 174 ( 3.2A)
None
None
 1.16A 2zifB-3n2xA:
undetectable		 2zifB-3n2xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 THR A  15
GLY A 217
ASP A  49
GLY A 172
LEU A 211
 None
 1.14A 3eeyF-3n2xA:
undetectable		 3eeyF-3n2xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 ILE A  17
ALA A 218
THR A 210
LEU A 211
 None
 0.64A 3hrdA-3n2xA:
undetectable
3hrdB-3n2xA:
undetectable		 3hrdA-3n2xA:
22.10
3hrdB-3n2xA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 5 PRO A  19
SER A 220
LEU A  39
SER A  22
 None
 1.27A 3ijxH-3n2xA:
undetectable		 3ijxH-3n2xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 10 SER A  61
VAL A 266
SER A  56
GLY A  55
GLY A  57
 None
None
MCL  A 174 ( 3.8A)
MCL  A 174 ( 3.2A)
MCL  A 174 ( 3.6A)
 1.44A 3ixlA-3n2xA:
undetectable		 3ixlA-3n2xA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 7 TYR A 259
LEU A 261
LEU A 302
THR A 251
 None
 0.99A 3lm8B-3n2xA:
undetectable
3lm8D-3n2xA:
undetectable		 3lm8B-3n2xA:
20.63
3lm8D-3n2xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 5 VAL A  21
LEU A  39
ILE A  40
VAL A  48
 None
 0.89A 4a9kB-3n2xA:
undetectable		 4a9kB-3n2xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		6 / 12 ASN A 224
ILE A 269
GLY A 202
ALA A 218
SER A 220
GLY A 223
 None
None
MCL  A 174 ( 3.8A)
None
None
None
 1.45A 4e1gA-3n2xA:
undetectable		 4e1gA-3n2xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 HIS A  78
ASP A  42
ASP A  32
ILE A  24
 None
 0.93A 4k0bA-3n2xA:
undetectable		 4k0bA-3n2xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 HIS A  78
ASP A  42
ASP A  32
ILE A  24
 None
 0.92A 4l7iA-3n2xA:
undetectable		 4l7iA-3n2xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 8 ILE A 115
GLY A  88
VAL A 138
SER A 137
 EDO  A   1 (-3.6A)
EDO  A   1 (-3.4A)
None
None
 0.83A 4r20A-3n2xA:
undetectable		 4r20A-3n2xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 GLY A  57
GLU A  59
LEU A 299
LEU A 303
ALA A 226
 MCL  A 174 ( 3.6A)
None
None
None
None
 1.09A 4wcxC-3n2xA:
5.8		 4wcxC-3n2xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 7 THR A 210
LEU A 211
LEU A 207
THR A  15
 None
 0.92A 4z90A-3n2xA:
undetectable
4z90B-3n2xA:
undetectable
4z90C-3n2xA:
undetectable
4z90D-3n2xA:
undetectable
4z90E-3n2xA:
undetectable		 4z90A-3n2xA:
22.19
4z90B-3n2xA:
22.19
4z90C-3n2xA:
22.19
4z90D-3n2xA:
22.19
4z90E-3n2xA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 ILE A 255
LEU A 252
GLY A 223
GLY A  55
PHE A 265
 None
None
None
MCL  A 174 ( 3.2A)
None
 1.12A 5d4uB-3n2xA:
undetectable		 5d4uB-3n2xA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		4 / 5 GLU A  99
ALA A  65
GLU A  96
ASN A  93
 None
 1.24A 5dwkC-3n2xA:
undetectable		 5dwkC-3n2xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		3 / 3 ILE A 173
ILE A 219
MET A 186
 MCL  A 174 ( 3.6A)
MCL  A 174 ( 3.7A)
None
 0.71A 5i9yA-3n2xA:
undetectable		 5i9yA-3n2xA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 LEU A  43
GLY A 277
CYH A 276
LEU A 299
ILE A 273
 None
 1.28A 5y2tA-3n2xA:
undetectable		 5y2tA-3n2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3n2x UNCHARACTERIZED
PROTEIN YAGE
(Escherichia
coli) 		5 / 12 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
 None
 1.15A 6brdB-3n2xA:
undetectable		 6brdB-3n2xA:
14.48