SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 GLY B 434
ASP B 225
SER B 433
ALA B 287
 None
 0.95A 1gxsA-3n2zB:
8.8
1gxsB-3n2zB:
undetectable		 1gxsA-3n2zB:
19.34
1gxsB-3n2zB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 6 THR B 461
ASN B 463
LEU B 465
ASP B 466
 None
 1.35A 1mxdA-3n2zB:
undetectable		 1mxdA-3n2zB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		3 / 3 SER B 179
GLY B 178
ARG B 460
 None
 0.69A 1t9wA-3n2zB:
undetectable		 1t9wA-3n2zB:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 4 PHE B 218
ASP B 378
PHE B 380
VAL B 284
 None
 1.41A 1w0fA-3n2zB:
undetectable		 1w0fA-3n2zB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY B 178
GLY B 181
GLY B 182
LEU B 200
ASN B 426
 None
 1.06A 1xdsA-3n2zB:
undetectable		 1xdsA-3n2zB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 8 TYR B 192
TYR B 180
GLU B 366
PHE B  60
 None
 1.12A 2ha4A-3n2zB:
12.7		 2ha4A-3n2zB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.21A 3e7gA-3n2zB:
undetectable
3e7gB-3n2zB:
0.0		 3e7gA-3n2zB:
21.97
3e7gB-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TRP B 187
MET B 410
ILE B 407
TRP B 406
 None
 1.20A 3e7gA-3n2zB:
0.4
3e7gB-3n2zB:
0.0		 3e7gA-3n2zB:
21.97
3e7gB-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.17A 3e7gC-3n2zB:
undetectable
3e7gD-3n2zB:
undetectable		 3e7gC-3n2zB:
21.97
3e7gD-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.28A 3ej8A-3n2zB:
0.4
3ej8B-3n2zB:
undetectable		 3ej8A-3n2zB:
21.97
3ej8B-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TRP B 187
MET B 410
ILE B 407
TRP B 406
 None
 1.29A 3ej8A-3n2zB:
0.4
3ej8B-3n2zB:
undetectable		 3ej8A-3n2zB:
21.97
3ej8B-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.36A 3ej8C-3n2zB:
undetectable
3ej8D-3n2zB:
0.3		 3ej8C-3n2zB:
21.97
3ej8D-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TRP B 187
MET B 410
ILE B 407
TRP B 406
 None
 1.24A 3ej8C-3n2zB:
undetectable
3ej8D-3n2zB:
0.3		 3ej8C-3n2zB:
21.97
3ej8D-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TYR B 335
GLU B 348
TRP B 278
LEU B 331
 None
 1.28A 3k8mA-3n2zB:
undetectable		 3k8mA-3n2zB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 8 ASP B  95
HIS B 456
LEU B  73
CYH B 100
 NAG  B   1 ( 4.6A)
None
None
None
 0.96A 3lm8B-3n2zB:
undetectable
3lm8D-3n2zB:
undetectable		 3lm8B-3n2zB:
19.69
3lm8D-3n2zB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TYR B 411
ILE B 407
PHE B 209
MET B 369
 None
 1.17A 3tvxB-3n2zB:
undetectable		 3tvxB-3n2zB:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS B 456
TYR B  89
GLY B 178
SER B 179
GLY B 355
 None
 1.17A 4blvB-3n2zB:
undetectable		 4blvB-3n2zB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 8 TRP B 187
MET B 410
ILE B 407
TRP B 406
 None
 1.29A 4cx7A-3n2zB:
undetectable
4cx7B-3n2zB:
undetectable		 4cx7A-3n2zB:
21.06
4cx7B-3n2zB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 8 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.23A 4cx7C-3n2zB:
undetectable
4cx7D-3n2zB:
undetectable		 4cx7C-3n2zB:
21.06
4cx7D-3n2zB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY B 413
GLY B 412
ILE B 407
VAL B 213
ILE B 206
 None
 1.27A 4fglA-3n2zB:
3.5
4fglB-3n2zB:
3.6		 4fglA-3n2zB:
19.56
4fglB-3n2zB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		3 / 3 ASP B 153
TRP B 359
SER B 128
 None
 1.07A 4lrhA-3n2zB:
undetectable		 4lrhA-3n2zB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 TRP B 187
MET B 410
ILE B 407
TRP B 406
 None
 1.24A 4nosA-3n2zB:
undetectable
4nosB-3n2zB:
undetectable		 4nosA-3n2zB:
22.04
4nosB-3n2zB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 7 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.26A 4nosC-3n2zB:
undetectable
4nosD-3n2zB:
undetectable		 4nosC-3n2zB:
22.04
4nosD-3n2zB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 11 GLY B 413
GLY B 412
ILE B 407
GLY B 435
ILE B 206
 None
 1.14A 4qoiA-3n2zB:
3.5
4qoiB-3n2zB:
3.6		 4qoiA-3n2zB:
19.65
4qoiB-3n2zB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 12 GLN B 208
VAL B 213
GLY B 427
ASP B 430
LEU B 459
 None
 1.03A 5hg0A-3n2zB:
2.5		 5hg0A-3n2zB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 8 THR B  90
ALA B 202
ASP B 458
SER B 425
 None
 1.12A 5l5fY-3n2zB:
undetectable
5l5fZ-3n2zB:
undetectable		 5l5fY-3n2zB:
18.59
5l5fZ-3n2zB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 5 MET B 481
TYR B  89
GLY B 177
GLY B 178
 None
 0.69A 5x7pA-3n2zB:
undetectable		 5x7pA-3n2zB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		4 / 6 MET B 481
TYR B  89
GLY B 177
GLY B 178
 None
 0.75A 5x7pB-3n2zB:
undetectable		 5x7pB-3n2zB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY B 104
TRP B 107
TYR B 291
TYR B 293
LEU B 457
 None
 1.50A 6bp4A-3n2zB:
undetectable		 6bp4A-3n2zB:
18.89