SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		4 / 4 TRP C 105
LEU C  75
ARG C  27
THR C  14
 None
None
None
FMN  C 134 (-3.5A)
 1.50A 1ao8A-3n3aC:
0.8		 1ao8A-3n3aC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 VAL C  62
LEU C  66
VAL C  96
GLY C  94
ALA C  93
 None
 1.08A 4coxC-3n3aC:
undetectable		 4coxC-3n3aC:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 LEU C  66
VAL C  46
VAL C  78
TYR C  42
PRO C  59
 None
 1.42A 4g1qA-3n3aC:
undetectable		 4g1qA-3n3aC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 LEU C  66
VAL C  46
VAL C  78
TYR C  42
PRO C  59
 None
 1.40A 4id5A-3n3aC:
undetectable		 4id5A-3n3aC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 LEU C  66
VAL C  46
VAL C  78
TYR C  42
PRO C  59
 None
 1.41A 4ifvA-3n3aC:
undetectable		 4ifvA-3n3aC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 LEU C  66
VAL C  46
VAL C  78
TYR C  42
PRO C  59
 None
 1.41A 4ig3A-3n3aC:
undetectable		 4ig3A-3n3aC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 ALA C  57
VAL C  58
PHE C  86
SER C  81
GLY C  91
 None
None
FMN  C 134 (-3.6A)
FMN  C 134 ( 4.2A)
FMN  C 134 (-3.9A)
 1.07A 4mm4B-3n3aC:
undetectable		 4mm4B-3n3aC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3n3a PROTEIN NRDI
(Escherichia
coli) 		5 / 12 ILE C  97
GLY C  94
GLY C  91
ALA C  89
ILE C  79
 None
None
FMN  C 134 (-3.9A)
FMN  C 134 (-3.6A)
None
 1.03A 6iftA-3n3aC:
undetectable		 6iftA-3n3aC:
20.35