SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		4 / 6 ILE A3614
GLU A3619
ARG A3725
ASP A3655
 None
 0.94A 1mt1B-3n3uA:
undetectable
1mt1C-3n3uA:
undetectable		 1mt1B-3n3uA:
19.39
1mt1C-3n3uA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.01A 1qzfA-3n3uA:
undetectable		 1qzfA-3n3uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.01A 1qzfB-3n3uA:
undetectable		 1qzfB-3n3uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.01A 1qzfC-3n3uA:
undetectable		 1qzfC-3n3uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.01A 1qzfD-3n3uA:
undetectable		 1qzfD-3n3uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.01A 1qzfE-3n3uA:
undetectable		 1qzfE-3n3uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 LEU A3502
PHE A3691
GLY A3706
ALA A3707
SER A3703
 None
 1.00A 2aylA-3n3uA:
undetectable		 2aylA-3n3uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 12 LEU A3502
PHE A3691
GLY A3706
ALA A3707
SER A3703
 None
 1.01A 3kk6A-3n3uA:
undetectable		 3kk6A-3n3uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		3 / 3 VAL A3771
SER A3767
LEU A3708
 None
 0.73A 3n8xA-3n3uA:
undetectable		 3n8xA-3n3uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		4 / 7 GLN A3643
GLU A3646
PHE A3719
PRO A3718
 None
 1.05A 3ql6A-3n3uA:
undetectable		 3ql6A-3n3uA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 11 ALA A3695
LEU A3502
LEU A3708
ILE A3580
LEU A3775
 None
 1.12A 3tqbA-3n3uA:
undetectable		 3tqbA-3n3uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		4 / 6 GLU A3751
TYR A3710
VAL A3704
PHE A3746
 None
 1.06A 4a97E-3n3uA:
undetectable		 4a97E-3n3uA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		4 / 7 GLU A3751
TYR A3710
VAL A3704
PHE A3746
 None
 1.11A 4a97H-3n3uA:
undetectable		 4a97H-3n3uA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		3 / 3 THR A3688
ASN A3732
PHE A3743
 None
 0.67A 4pd9A-3n3uA:
0.3		 4pd9A-3n3uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 9 LEU A3502
VAL A3584
LEU A3775
ILE A3580
PHE A3743
 None
 1.23A 4r38C-3n3uA:
undetectable		 4r38C-3n3uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA
(Histophilus
somni) 		5 / 10 GLY A3706
ALA A3695
VAL A3705
GLU A3506
ILE A3734
 None
 1.05A 5i3cB-3n3uA:
undetectable		 5i3cB-3n3uA:
22.86