SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.40A 1dhiA-3n3wA:
undetectable		 1dhiA-3n3wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.41A 1dhjA-3n3wA:
undetectable		 1dhjA-3n3wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.42A 1draA-3n3wA:
undetectable		 1draA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.38A 1drbA-3n3wA:
undetectable		 1drbA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.41A 1ra2A-3n3wA:
undetectable		 1ra2A-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.43A 1ra3A-3n3wA:
undetectable		 1ra3A-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.39A 1ra8A-3n3wA:
undetectable		 1ra8A-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 10 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
 None
 1.29A 1tdrB-3n3wA:
undetectable		 1tdrB-3n3wA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.42A 2drcA-3n3wA:
undetectable		 2drcA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.44A 3drcA-3n3wA:
undetectable		 3drcA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 9 ILE A 118
ILE A 122
LEU A  11
LEU A  21
ALA A  24
 None
 1.05A 3ozvB-3n3wA:
undetectable		 3ozvB-3n3wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.38A 4ej1A-3n3wA:
undetectable		 4ej1A-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		3 / 3 LYS A 107
PRO A 108
SER A 109
 None
 0.33A 4k50I-3n3wA:
undetectable		 4k50I-3n3wA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ILE A 122
ALA A 135
ILE A  83
LEU A  89
LEU A   7
ILE A 118
 None
 1.26A 4m2xC-3n3wA:
undetectable		 4m2xC-3n3wA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 12 LEU A  21
LEU A  11
SER A  86
LEU A 115
ILE A 118
 None
 1.11A 4x1fA-3n3wA:
undetectable		 4x1fA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 12 LEU A  25
LEU A   7
SER A  86
LEU A 115
ILE A 118
 None
 0.95A 4x1fA-3n3wA:
undetectable		 4x1fA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 12 LEU A  21
LEU A  11
SER A  86
LEU A 115
ILE A 118
 None
 1.08A 4x1gA-3n3wA:
undetectable		 4x1gA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 12 LEU A  25
LEU A   7
SER A  86
LEU A 115
ILE A 118
 None
 0.99A 4x1gA-3n3wA:
undetectable		 4x1gA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		3 / 3 LEU A 138
PHE A  80
ILE A 139
 None
 0.76A 5dzk1-3n3wA:
undetectable
5dzkF-3n3wA:
undetectable
5dzkM-3n3wA:
undetectable		 5dzk1-3n3wA:
0.81
5dzkF-3n3wA:
25.63
5dzkM-3n3wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.46A 5eajA-3n3wA:
undetectable		 5eajA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 12 LEU A 115
ILE A 119
GLY A  43
LEU A  89
ASN A  36
 None
 0.98A 5nfjA-3n3wA:
undetectable		 5nfjA-3n3wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		6 / 12 ALA A  24
LEU A   7
ILE A 134
ARG A 137
LEU A 138
ILE A 119
 None
 1.48A 5ujxA-3n3wA:
undetectable		 5ujxA-3n3wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3n3w RIBONUCLEASE III
(Campylobacter
jejuni) 		5 / 10 HIS A  57
ALA A 131
GLY A 120
ILE A 122
ALA A 135
 None
 1.32A 5vyhA-3n3wA:
undetectable		 5vyhA-3n3wA:
18.55