SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
HIS A 296
MET A 365
ASN A 405
GLN A 453
None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
0.83A 1xlxA-3n3zA:
41.1
1xlxA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
HIS A 296
MET A 365
GLN A 453
PHE A 456
None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.63A 1xlxA-3n3zA:
41.1
1xlxA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
HIS A 296
MET A 365
GLN A 453
PHE A 456
None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.57A 1xlxB-3n3zA:
40.8
1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 292
MET A 365
PHE A 251
GLN A 453
PHE A 456
ZN  A 507 (-3.5A)
None
IBM  A   1 ( 4.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
1.30A 1xlxB-3n3zA:
40.8
1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASP A 402
GLN A 453
PHE A 456
None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.58A 1xomA-3n3zA:
41.3
1xomA-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
3 / 3 ASN A 405
TRP A 416
GLN A 453
IBM  A   1 (-3.5A)
None
IBM  A   1 (-3.5A)
0.86A 1xoqA-3n3zA:
41.3
1xoqA-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
3 / 3 MET A 365
ASN A 405
GLN A 453
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
0.88A 1xoqB-3n3zA:
41.3
1xoqB-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASP A 402
GLN A 453
PHE A 456
None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.51A 1xosA-3n3zA:
41.3
1xosA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASN A 405
GLN A 453
PHE A 456
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.80A 1xotB-3n3zA:
41.2
1xotB-3n3zA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 6 LEU A 205
MET A 263
MET A 218
LEU A 196
None
1.38A 2oz7A-3n3zA:
undetectable
2oz7A-3n3zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 220
LEU A 222
VAL A 268
MET A 286
LEU A 239
None
1.30A 2prgB-3n3zA:
undetectable
2prgB-3n3zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
0.99A 2xadA-3n3zA:
undetectable
2xadA-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
1.02A 2xadB-3n3zA:
undetectable
2xadB-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
1.02A 2xadC-3n3zA:
undetectable
2xadC-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
1.01A 2xadD-3n3zA:
undetectable
2xadD-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 7 LEU A 483
PHE A 465
LEU A 461
PHE A 456
None
None
None
IBM  A   1 (-3.4A)
1.00A 3asnP-3n3zA:
3.3
3asnW-3n3zA:
undetectable
3asnP-3n3zA:
21.17
3asnW-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 7 LEU A 483
PHE A 465
LEU A 461
PHE A 456
None
None
None
IBM  A   1 (-3.4A)
1.01A 3asoP-3n3zA:
3.2
3asoW-3n3zA:
undetectable
3asoP-3n3zA:
21.17
3asoW-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
3 / 3 CYH A 241
HIS A 243
PHE A 240
None
1.10A 3cr4X-3n3zA:
0.0
3cr4X-3n3zA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.4A)
0.60A 3g4lB-3n3zA:
41.0
3g4lB-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
None
0.85A 3g4lC-3n3zA:
41.1
3g4lC-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 252
MET A 365
ASP A 402
TRP A 416
GLN A 453
None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.5A)
0.62A 3g4lD-3n3zA:
40.9
3g4lD-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 7 HIS A 252
GLN A 453
PHE A 456
VAL A 460
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
0.57A 3jwqC-3n3zA:
41.8
3jwqC-3n3zA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 7 HIS A 256
GLN A 453
PHE A 456
VAL A 460
ZN  A 507 (-3.8A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
0.83A 3jwqC-3n3zA:
41.8
3jwqC-3n3zA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 5 GLN A 304
GLU A 322
THR A 363
HIS A 292
None
None
None
ZN  A 507 (-3.5A)
1.48A 3n58A-3n3zA:
undetectable
3n58A-3n3zA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 MET A 479
SER A 486
VAL A 475
PRO A 199
LEU A 270
None
1.19A 3v8vA-3n3zA:
undetectable
3v8vA-3n3zA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 HIS A 325
VAL A 328
HIS A 296
PRO A 297
LEU A 311
MG  A 508 ( 4.8A)
None
None
None
None
1.42A 3wfhA-3n3zA:
undetectable
3wfhB-3n3zA:
undetectable
3wfhA-3n3zA:
19.44
3wfhB-3n3zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 6 LEU A 483
PHE A 465
LEU A 461
PHE A 456
None
None
None
IBM  A   1 (-3.4A)
1.03A 3wg7C-3n3zA:
3.3
3wg7J-3n3zA:
1.4
3wg7C-3n3zA:
21.17
3wg7J-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 6 LEU A 483
PHE A 465
LEU A 461
PHE A 456
None
None
None
IBM  A   1 (-3.4A)
0.97A 3wg7P-3n3zA:
3.2
3wg7W-3n3zA:
undetectable
3wg7P-3n3zA:
21.17
3wg7W-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 8 CYH A 401
SER A 404
VAL A 468
ILE A 396
MET A 267
None
1.43A 4oj4A-3n3zA:
2.1
4oj4A-3n3zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
5 / 12 ALA A 406
LEU A 420
MET A 365
HIS A 368
LEU A 483
IBM  A   1 ( 4.7A)
IBM  A   1 (-4.8A)
None
None
None
1.08A 4zn7A-3n3zA:
undetectable
4zn7A-3n3zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 5 LEU A 483
PHE A 465
LEU A 461
PHE A 456
None
None
None
IBM  A   1 (-3.4A)
1.02A 5x19C-3n3zA:
undetectable
5x19J-3n3zA:
undetectable
5x19C-3n3zA:
21.17
5x19J-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo
sapiens)
4 / 8 HIS A 252
TYR A 299
GLU A 422
CYH A 419
None
1.30A 6gneB-3n3zA:
undetectable
6gneB-3n3zA:
22.33