SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE P 165
ARG P 150
THR P 190
LEU P  98
 None
 0.99A 2einN-3n40P:
undetectable
2einW-3n40P:
undetectable		 2einN-3n40P:
21.28
2einW-3n40P:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA P 167
LEU P 147
ARG P 144
LEU P 175
PRO P 170
 None
None
ACT  P   2 (-3.8A)
None
None
 0.94A 2qxsA-3n40P:
undetectable		 2qxsA-3n40P:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA P 167
LEU P 147
ARG P 144
LEU P 175
PRO P 170
 None
None
ACT  P   2 (-3.8A)
None
None
 0.89A 2qxsB-3n40P:
undetectable		 2qxsB-3n40P:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE P 165
ARG P 150
THR P 190
LEU P  98
 None
 0.94A 3ag3A-3n40P:
undetectable
3ag3J-3n40P:
undetectable		 3ag3A-3n40P:
21.28
3ag3J-3n40P:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ASN P 363
GLU P 388
GLU P 366
GLU P 367
 None
 1.22A 4mj8C-3n40P:
undetectable		 4mj8C-3n40P:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 LEU P 175
ILE P 101
LEU P  98
THR P 160
VAL P 114
 None
None
None
ACT  P   2 (-3.4A)
None
 0.98A 4nkvB-3n40P:
undetectable		 4nkvB-3n40P:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 LYS P 297
ARG P 262
VAL P 261
 None
 0.96A 4x3uA-3n40P:
undetectable
4x3uB-3n40P:
undetectable		 4x3uA-3n40P:
8.98
4x3uB-3n40P:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA P 167
LEU P 147
ARG P 144
LEU P 175
PRO P 170
 None
None
ACT  P   2 (-3.8A)
None
None
 0.92A 4xi3A-3n40P:
undetectable		 4xi3A-3n40P:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA P 167
LEU P 147
ARG P 144
LEU P 175
PRO P 170
 None
None
ACT  P   2 (-3.8A)
None
None
 0.88A 4xi3B-3n40P:
undetectable		 4xi3B-3n40P:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 4 VAL P 332
GLU P 203
GLY P 201
LEU P 215
 None
 1.39A 5g5gC-3n40P:
undetectable		 5g5gC-3n40P:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 HIS P 195
ASN P 103
ALA P 105
 None
 0.61A 5n4tB-3n40P:
undetectable		 5n4tB-3n40P:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE P 165
ARG P 150
THR P 190
LEU P  98
 None
 0.93A 5xdqN-3n40P:
undetectable
5xdqW-3n40P:
undetectable		 5xdqN-3n40P:
21.28
5xdqW-3n40P:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE P 165
ARG P 150
THR P 190
LEU P  98
 None
 0.95A 5z86N-3n40P:
undetectable
5z86W-3n40P:
undetectable		 5z86N-3n40P:
21.28
5z86W-3n40P:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE P 165
ARG P 150
THR P 190
LEU P  98
 None
 0.99A 5zcoN-3n40P:
undetectable
5zcoW-3n40P:
undetectable		 5zcoN-3n40P:
21.28
5zcoW-3n40P:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ARG P 262
THR P 239
PRO P 240
PRO P 307
 None
 1.26A 6a4iB-3n40P:
undetectable		 6a4iB-3n40P:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 TYR P 301
PRO P 304
LEU P 305
 None
 0.92A 6beoA-3n40P:
undetectable		 6beoA-3n40P:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3n40 P62 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ILE P 319
ILE P 321
VAL P 233
ILE P 231
PRO P 139
 None
 1.08A 6hlpA-3n40P:
undetectable		 6hlpA-3n40P:
21.01