SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		7 / 12 PHE A 104
GLY A 105
GLY A 110
ILE A 127
MET A 129
SER A 135
ALA A 141
 SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 4.0A)
 0.53A 1v2xA-3n4kA:
15.7		 1v2xA-3n4kA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		6 / 11 GLY A 105
GLY A 110
ILE A 127
MET A 129
SER A 135
ALA A 141
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 4.0A)
 0.78A 1x7pA-3n4kA:
16.7
1x7pB-3n4kA:
17.0		 1x7pA-3n4kA:
20.21
1x7pB-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 10 GLY A 105
GLY A 110
ILE A 127
MET A 129
ALA A 141
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 ( 4.0A)
 0.46A 1x7pA-3n4kA:
16.7
1x7pB-3n4kA:
17.0		 1x7pA-3n4kA:
20.21
1x7pB-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A  29
ASN A  14
LEU A  21
THR A  25
LEU A   6
 None
 1.38A 3fsuA-3n4kA:
undetectable		 3fsuA-3n4kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 11 LEU A  83
GLY A 105
ILE A 127
MET A 129
SER A 135
 SAH  A 201 (-4.1A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
 0.50A 3gyqB-3n4kA:
15.9		 3gyqB-3n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		9 / 12 ASN A  14
LEU A  83
THR A  85
GLY A 105
GLY A 110
ILE A 127
MET A 129
SER A 135
ASN A 137
 None
SAH  A 201 (-4.1A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
None
 0.71A 3nk7A-3n4kA:
16.7		 3nk7A-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		8 / 12 LEU A  83
THR A  85
GLU A 107
GLY A 110
ILE A 127
MET A 129
SER A 135
ASN A 137
 SAH  A 201 (-4.1A)
SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
None
 1.25A 3nk7A-3n4kA:
16.7		 3nk7A-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 THR A  85
GLY A 105
MET A 129
SER A 135
ASN A 137
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
None
 0.88A 3nk7A-3n4kA:
16.7		 3nk7A-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		8 / 12 ASN A  14
LEU A  83
PHE A 104
GLY A 105
GLY A 110
ILE A 127
MET A 129
SER A 135
 None
SAH  A 201 (-4.1A)
SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
 0.70A 3nk7B-3n4kA:
16.6		 3nk7B-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		7 / 12 LEU A  83
GLY A 105
GLU A 107
GLY A 110
ILE A 127
MET A 129
SER A 135
 SAH  A 201 (-4.1A)
SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
 1.19A 3nk7B-3n4kA:
16.6		 3nk7B-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 PHE A  66
HIS A  60
GLU A   8
ILE A 115
 None
 1.32A 4cx7A-3n4kA:
undetectable
4cx7B-3n4kA:
undetectable		 4cx7A-3n4kA:
15.30
4cx7B-3n4kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 ARG A 109
GLY A 105
ASN A  14
GLU A 107
 None
SAH  A 201 (-3.1A)
None
None
 1.10A 4g0vA-3n4kA:
undetectable		 4g0vA-3n4kA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 TYR A 101
ILE A 115
LEU A 116
GLY A 105
PHE A  66
 None
None
None
SAH  A 201 (-3.1A)
None
 1.12A 5d4uA-3n4kA:
undetectable		 5d4uA-3n4kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A  83
PHE A 104
ARG A 126
MET A 136
ALA A 141
 SAH  A 201 (-4.1A)
SAH  A 201 (-4.9A)
None
SAH  A 201 (-3.9A)
SAH  A 201 ( 4.0A)
 0.96A 5h5fA-3n4kA:
9.7		 5h5fA-3n4kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		7 / 12 GLY A 105
GLY A 110
ARG A 126
ILE A 127
SER A 135
LEU A 138
ALA A 141
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
None
SAH  A 201 (-3.8A)
SAH  A 201 (-3.3A)
SAH  A 201 (-4.3A)
SAH  A 201 ( 4.0A)
 0.57A 5l0zA-3n4kA:
17.5		 5l0zA-3n4kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3n4k RNA
METHYLTRANSFERASE
(Yersinia
pestis) 		6 / 10 GLY A 105
GLY A 110
ILE A 127
SER A 135
LEU A 138
ALA A 141
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.3A)
SAH  A 201 (-4.3A)
SAH  A 201 ( 4.0A)
 0.44A 5l0zB-3n4kA:
7.6		 5l0zB-3n4kA:
21.92