SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		5 / 12 TYR A 661
ASP A 582
LEU A 662
GLY A 476
ILE A 654
 None
 0.99A 1pbkA-3n4pA:
undetectable		 1pbkA-3n4pA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		5 / 12 THR A 445
LEU A 458
VAL A 460
VAL A 519
VAL A 656
 None
 0.99A 1q23H-3n4pA:
undetectable
1q23I-3n4pA:
undetectable		 1q23H-3n4pA:
21.36
1q23I-3n4pA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		4 / 8 ASP A 615
LEU A 605
LEU A 620
LEU A 652
 None
 0.97A 2bfpB-3n4pA:
undetectable		 2bfpB-3n4pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		4 / 5 LEU A 620
ILE A 610
SER A 607
GLY A 491
 None
 0.85A 2otfA-3n4pA:
undetectable		 2otfA-3n4pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		4 / 5 LEU A 548
ALA A 507
ILE A 508
SER A 504
 None
 1.15A 2othA-3n4pA:
undetectable		 2othA-3n4pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		3 / 3 ARG A 670
ARG A 672
PRO A 567
 None
 1.12A 2wljA-3n4pA:
undetectable		 2wljA-3n4pA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3n4p TERMINASE SUBUNIT
UL89 PROTEIN
(Human
betaherpesvirus
5) 		3 / 3 ASN A 538
ALA A 540
ARG A 544
 None
 0.39A 5cvtB-3n4pA:
undetectable		 5cvtB-3n4pA:
20.22