SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.74A 1ictB-3n4xA:
undetectable		 1ictB-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 171
TYR A 156
LEU A 157
LYS A 177
 None
 1.18A 1rmtB-3n4xA:
undetectable		 1rmtB-3n4xA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 1.04A 1tyrA-3n4xA:
undetectable		 1tyrA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 119
LYS A 139
VAL A 137
 None
 0.69A 3brfA-3n4xA:
undetectable		 3brfA-3n4xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.84A 3d2tB-3n4xA:
undetectable		 3d2tB-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.88A 4d7bA-3n4xA:
undetectable		 4d7bA-3n4xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 1.04A 4ikiB-3n4xA:
undetectable		 4ikiB-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.83A 4iklA-3n4xA:
undetectable
4iklB-3n4xA:
undetectable		 4iklA-3n4xA:
20.73
4iklB-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.91A 5bojA-3n4xA:
undetectable		 5bojA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 1.02A 5l4iA-3n4xA:
undetectable		 5l4iA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 164
SER A 166
SER A 167
 None
 0.61A 6bpyA-3n4xA:
undetectable		 6bpyA-3n4xA:
17.57