SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		6 / 10 ALA A  36
LEU A  79
LEU A  77
LEU A  66
LYS A  65
LEU A  50
 None
 1.43A 2riwA-3n53A:
undetectable
2riwB-3n53A:
undetectable		 2riwA-3n53A:
19.38
2riwB-3n53A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		4 / 6 LEU A 118
ILE A   4
ILE A  54
LEU A  79
 None
 0.92A 2xkwB-3n53A:
undetectable		 2xkwB-3n53A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		6 / 10 ALA A  36
LEU A  79
LEU A  77
LEU A  66
LYS A  65
LEU A  50
 None
 1.48A 2xn6A-3n53A:
undetectable
2xn6B-3n53A:
undetectable		 2xn6A-3n53A:
19.02
2xn6B-3n53A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		5 / 10 LEU A  37
GLU A  33
LEU A  62
GLY A  96
LEU A  77
 None
 1.20A 5dx3A-3n53A:
undetectable		 5dx3A-3n53A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		4 / 8 LEU A  37
LEU A  50
MET A  52
ILE A  54
 None
 1.02A 5mzjA-3n53A:
undetectable		 5mzjA-3n53A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
(Pelobacter
carbinolicus) 		4 / 5 ILE A   4
LEU A  47
ARG A  14
LEU A  80
 None
 0.85A 6nmpN-3n53A:
undetectable
6nmpW-3n53A:
undetectable		 6nmpN-3n53A:
13.12
6nmpW-3n53A:
16.54