SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 252
PHE A 270
PHE A  32
LEU A 265
 None
 1.21A 1ea1A-3n5lA:
undetectable		 1ea1A-3n5lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 237
PHE A 249
MET A  54
SER A  55
 None
 1.20A 1wrlC-3n5lA:
undetectable		 1wrlC-3n5lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 104
LEU A 237
PHE A 249
SER A  55
 None
 1.18A 1wrlC-3n5lA:
undetectable		 1wrlC-3n5lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 4 LYS A  44
ALA A  64
PHE A  65
GLY A  33
 None
 1.22A 2rddA-3n5lA:
undetectable		 2rddA-3n5lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 182
ARG A 205
GLU A  38
SER A  39
 None
 1.22A 2zt7A-3n5lA:
3.2		 2zt7A-3n5lA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  35
THR A 107
PHE A 270
PHE A  50
 None
 1.37A 3em0A-3n5lA:
undetectable		 3em0A-3n5lA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 106
THR A 107
GLU A 201
THR A 200
 None
None
UNL  A 401 ( 3.2A)
None
 1.28A 3glqA-3n5lA:
undetectable		 3glqA-3n5lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 106
THR A 107
GLU A 201
THR A 200
 None
None
UNL  A 401 ( 3.2A)
None
 1.35A 3glqB-3n5lA:
undetectable		 3glqB-3n5lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 249
TYR A 252
VAL A  62
PHE A  50
 None
 1.28A 3ltwA-3n5lA:
undetectable		 3ltwA-3n5lA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 106
THR A 107
GLU A 201
THR A 200
 None
None
UNL  A 401 ( 3.2A)
None
 1.44A 3n58A-3n5lA:
undetectable		 3n58A-3n5lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 271
THR A 107
LEU A 278
 None
 0.59A 3ondA-3n5lA:
undetectable		 3ondA-3n5lA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 271
THR A 107
LEU A 278
 None
 0.60A 3ondB-3n5lA:
undetectable		 3ondB-3n5lA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 147
GLY A 228
ASP A 229
THR A 151
ILE A 281
 None
None
UNL  A 401 ( 2.7A)
UNL  A 401 ( 3.7A)
None
 0.94A 3prsA-3n5lA:
undetectable		 3prsA-3n5lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 163
SER A 118
ILE A 226
LEU A 155
THR A 291
 EDO  A 411 (-3.9A)
None
None
None
None
 1.24A 3qg2B-3n5lA:
undetectable		 3qg2B-3n5lA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 7 ILE A  34
GLY A  33
PHE A 270
PHE A 249
LEU A 231
 None
 1.16A 3v7pA-3n5lA:
undetectable		 3v7pA-3n5lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  35
ILE A  73
GLY A  72
VAL A 232
ARG A 282
 None
None
EDO  A 429 (-3.5A)
None
EDO  A 414 (-3.9A)
 0.94A 4ac9B-3n5lA:
undetectable
4ac9C-3n5lA:
undetectable		 4ac9B-3n5lA:
21.50
4ac9C-3n5lA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 11 THR A 107
LEU A 262
PHE A  32
VAL A  62
ILE A  84
 None
 1.10A 4claA-3n5lA:
undetectable		 4claA-3n5lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		5 / 11 MET A  54
PHE A 248
PHE A  50
LEU A 262
THR A 107
 None
 1.35A 4dx7A-3n5lA:
1.8		 4dx7A-3n5lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		3 / 3 THR A 291
ALA A 163
ASN A 295
 None
EDO  A 411 (-3.9A)
EDO  A 411 (-3.7A)
 0.60A 5ersA-3n5lA:
2.7		 5ersA-3n5lA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 325
ARG A 321
ASP A 276
 None
 0.85A 6d8pA-3n5lA:
undetectable		 6d8pA-3n5lA:
17.50