SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		5 / 11 ARG X 233
LEU X 255
LEU X  86
ALA X 268
GLY X 272
 None
 1.21A 1cmaA-3n5nX:
undetectable
1cmaB-3n5nX:
undetectable		 1cmaA-3n5nX:
15.97
1cmaB-3n5nX:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ARG X  95
THR X 274
VAL X 275
ALA X 267
 None
 0.93A 1fo4B-3n5nX:
undetectable		 1fo4B-3n5nX:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M6E_X_SALX2000_1
(S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 GLN X 146
TRP X 117
MET X 187
VAL X 179
 None
 0.98A 1m6eX-3n5nX:
undetectable		 1m6eX-3n5nX:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		5 / 12 ALA X 268
GLY X 272
ARG X 233
LEU X 255
LEU X  86
 None
 1.14A 1mj2A-3n5nX:
undetectable
1mj2B-3n5nX:
undetectable		 1mj2A-3n5nX:
15.97
1mj2B-3n5nX:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 5 LEU X  86
VAL X 288
CYH X 292
ALA X 294
 None
None
SF4  X 400 (-2.2A)
SF4  X 400 ( 4.9A)
 1.06A 1mz9D-3n5nX:
undetectable		 1mz9D-3n5nX:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 1.01A 1v54N-3n5nX:
undetectable
1v54W-3n5nX:
undetectable		 1v54N-3n5nX:
18.74
1v54W-3n5nX:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 1.00A 2dyrN-3n5nX:
undetectable
2dyrW-3n5nX:
undetectable		 2dyrN-3n5nX:
18.74
2dyrW-3n5nX:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		3 / 3 LEU X 163
TRP X 117
TYR X 135
 None
 1.00A 3aicF-3n5nX:
undetectable		 3aicF-3n5nX:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 GLN X 253
GLY X 207
GLY X 219
ALA X 191
 None
 0.69A 3fpjB-3n5nX:
undetectable		 3fpjB-3n5nX:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ARG X 189
VAL X 116
PHE X 214
GLU X 106
 None
 1.41A 3n5vA-3n5nX:
undetectable
3n5vB-3n5nX:
undetectable		 3n5vA-3n5nX:
19.77
3n5vB-3n5nX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 6 LEU X 229
ALA X 234
ARG X 233
LEU X 248
 None
 1.06A 3ravA-3n5nX:
undetectable		 3ravA-3n5nX:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		5 / 12 GLY X 219
LEU X 251
GLY X 250
ALA X 208
PHE X 264
 None
 1.08A 3vywC-3n5nX:
undetectable		 3vywC-3n5nX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 6 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 0.95A 3wg7N-3n5nX:
undetectable
3wg7W-3n5nX:
undetectable		 3wg7N-3n5nX:
18.74
3wg7W-3n5nX:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		5 / 12 GLN X 216
GLY X 207
ALA X 191
GLN X 195
VAL X 220
 None
 1.14A 4azwA-3n5nX:
undetectable		 4azwA-3n5nX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ARG X 189
VAL X 116
PHE X 214
GLU X 106
 None
 1.41A 4d1nA-3n5nX:
undetectable
4d1nB-3n5nX:
undetectable		 4d1nA-3n5nX:
20.45
4d1nB-3n5nX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 0.97A 5b1bA-3n5nX:
undetectable
5b1bJ-3n5nX:
undetectable		 5b1bA-3n5nX:
18.74
5b1bJ-3n5nX:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 0.96A 5iy5A-3n5nX:
undetectable
5iy5J-3n5nX:
undetectable		 5iy5A-3n5nX:
18.74
5iy5J-3n5nX:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 6 ARG X 189
VAL X 116
PHE X 214
GLU X 106
 None
 1.34A 5unvA-3n5nX:
undetectable
5unvB-3n5nX:
undetectable		 5unvA-3n5nX:
19.77
5unvB-3n5nX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ARG X 189
VAL X 116
PHE X 214
GLU X 106
 None
 1.40A 5vujA-3n5nX:
undetectable
5vujB-3n5nX:
undetectable		 5vujA-3n5nX:
19.77
5vujB-3n5nX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 6 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 1.04A 5z86N-3n5nX:
undetectable
5z86W-3n5nX:
undetectable		 5z86N-3n5nX:
18.74
5z86W-3n5nX:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens) 		4 / 6 ILE X 209
ARG X 102
THR X 144
LEU X 145
 None
 0.99A 5zcoN-3n5nX:
undetectable
5zcoW-3n5nX:
undetectable		 5zcoN-3n5nX:
18.74
5zcoW-3n5nX:
12.89