SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 11 SER A 173
LEU A  58
SER A  45
LEU A  50
VAL A 158
 None
 0.95A 1ee2A-3n6nA:
undetectable		 1ee2A-3n6nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 11 SER A 173
LEU A  58
SER A  45
LEU A  50
VAL A 158
 None
 0.93A 1ee2B-3n6nA:
undetectable		 1ee2B-3n6nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.14A 1p7lC-3n6nA:
undetectable		 1p7lC-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.14A 1p7lD-3n6nA:
undetectable		 1p7lD-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.16A 1rg9A-3n6nA:
undetectable		 1rg9A-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.16A 1rg9B-3n6nA:
undetectable		 1rg9B-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.14A 1rg9C-3n6nA:
undetectable		 1rg9C-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.14A 1rg9D-3n6nA:
undetectable		 1rg9D-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 LYS A 172
ASP A 233
ASP A 359
 BUP  A 464 ( 4.9A)
None
None
 1.17A 2br4A-3n6nA:
undetectable		 2br4A-3n6nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A 373
ASP A 329
SER A 299
 None
BUP  A 464 ( 4.1A)
None
 0.82A 2nxeA-3n6nA:
undetectable		 2nxeA-3n6nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A 373
ASP A 329
SER A 299
 None
BUP  A 464 ( 4.1A)
None
 0.84A 2nxeB-3n6nA:
undetectable		 2nxeB-3n6nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 6 GLY A 268
GLY A 261
PHE A 191
PHE A 297
 None
 0.96A 2qx6A-3n6nA:
undetectable
2qx6B-3n6nA:
undetectable		 2qx6A-3n6nA:
17.99
2qx6B-3n6nA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 6 ASN A 302
SER A 299
ALA A 326
ASP A 330
 None
 1.30A 3aruA-3n6nA:
undetectable		 3aruA-3n6nA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 GLY A 149
ASN A 182
PHE A 143
TYR A 148
 None
 1.32A 3ccfA-3n6nA:
undetectable		 3ccfA-3n6nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 11 ASP A  71
LEU A 241
SER A 242
PHE A 246
ILE A 301
 None
 1.47A 3ko0Q-3n6nA:
undetectable
3ko0R-3n6nA:
undetectable
3ko0S-3n6nA:
undetectable
3ko0T-3n6nA:
undetectable		 3ko0Q-3n6nA:
12.04
3ko0R-3n6nA:
12.04
3ko0S-3n6nA:
12.04
3ko0T-3n6nA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 9 ARG A  49
ASP A  47
PHE A  54
TYR A 276
LEU A  58
 None
 1.17A 3mjrA-3n6nA:
undetectable		 3mjrA-3n6nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 6 TYR A 120
ILE A 130
SER A 179
SER A 180
 None
 1.11A 3pmzD-3n6nA:
undetectable		 3pmzD-3n6nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		7 / 9 ASP A 238
SER A 289
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
None
BUP  A 464 ( 4.1A)
None
 1.00A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 9 THR A 294
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 None
None
None
BUP  A 464 ( 4.1A)
None
 0.58A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		7 / 9 ASP A 238
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
LEU A 375
 BUP  A 464 (-3.2A)
None
None
None
BUP  A 464 ( 4.1A)
None
None
 0.53A 3sfuB-3n6nA:
30.5		 3sfuB-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 11 ASP A 238
SER A 289
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
BUP  A 464 ( 4.1A)
 1.04A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		6 / 11 LYS A 159
ARG A 174
ASP A 238
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.63A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		6 / 11 LYS A 159
ARG A 174
ASP A 238
THR A 294
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.64A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 7 LYS A 346
LEU A 342
THR A 354
SER A 235
 None
None
None
BUP  A 464 (-2.9A)
 1.09A 4iklA-3n6nA:
undetectable
4iklB-3n6nA:
undetectable		 4iklA-3n6nA:
14.35
4iklB-3n6nA:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K50_E_ACTE501_0
(RNA POLYMERASE
3D-POL)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 4 CYH A 212
THR A 216
PHE A 217
LYS A 220
 None
 0.35A 4k50E-3n6nA:
50.2		 4k50E-3n6nA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K50_M_ACTM502_0
(RNA POLYMERASE
3D-POL)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 4 CYH A 212
THR A 216
PHE A 217
LYS A 220
 None
 0.34A 4k50M-3n6nA:
50.3		 4k50M-3n6nA:
54.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 LEU A 225
PRO A 226
ARG A 307
 None
 0.61A 4klrB-3n6nA:
undetectable		 4klrB-3n6nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 SER A 295
SER A 292
TYR A 327
GLU A 108
 None
 1.35A 4ms4A-3n6nA:
undetectable		 4ms4A-3n6nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 7 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.21A 4odjA-3n6nA:
undetectable		 4odjA-3n6nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 4 TYR A 154
THR A 272
GLY A 268
LEU A 187
 None
 1.43A 4w5nA-3n6nA:
undetectable		 4w5nA-3n6nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.18A 5a1iA-3n6nA:
undetectable		 5a1iA-3n6nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 7 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.18A 5a1iA-3n6nA:
undetectable		 5a1iA-3n6nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A  21
PRO A  40
ARG A 163
 None
None
BUP  A 464 (-2.6A)
 0.76A 5nd7B-3n6nA:
undetectable		 5nd7B-3n6nA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.17A 5t8sB-3n6nA:
undetectable		 5t8sB-3n6nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.20A 6fboA-3n6nA:
undetectable		 6fboA-3n6nA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 8 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.18A 6fcdA-3n6nA:
undetectable		 6fcdA-3n6nA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 7 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.19A 6g6rA-3n6nA:
undetectable		 6g6rA-3n6nA:
22.64