SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		3 / 3 GLU A 631
HIS A 496
ASP A 577
 None
 0.85A 1i9gA-3n6oA:
undetectable		 1i9gA-3n6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 10 SER A 417
GLY A 431
VAL A 428
GLU A 429
SER A 434
 None
 1.45A 1pk7C-3n6oA:
undetectable		 1pk7C-3n6oA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.03A 1qzfA-3n6oA:
undetectable		 1qzfA-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.03A 1qzfB-3n6oA:
undetectable		 1qzfB-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.04A 1qzfC-3n6oA:
undetectable		 1qzfC-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.03A 1qzfD-3n6oA:
undetectable		 1qzfD-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.03A 1qzfE-3n6oA:
undetectable		 1qzfE-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		3 / 3 LEU A 493
HIS A 496
LYS A 497
 None
 1.04A 1y7iA-3n6oA:
undetectable		 1y7iA-3n6oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.10A 2oipA-3n6oA:
undetectable		 2oipA-3n6oA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.08A 2oipE-3n6oA:
undetectable		 2oipE-3n6oA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		3 / 3 ARG A 453
ASP A 445
ASN A 451
 None
 0.89A 2zzmA-3n6oA:
undetectable		 2zzmA-3n6oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.04A 3hj3D-3n6oA:
undetectable		 3hj3D-3n6oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		3 / 3 ARG A 453
ASP A 445
ASP A 387
 None
 0.85A 4kicB-3n6oA:
undetectable		 4kicB-3n6oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.03A 4ky8A-3n6oA:
undetectable		 4ky8A-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.10A 4ky8B-3n6oA:
undetectable		 4ky8B-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.10A 4ky8C-3n6oA:
undetectable		 4ky8C-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.09A 4ky8D-3n6oA:
undetectable		 4ky8D-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.07A 4ky8E-3n6oA:
undetectable		 4ky8E-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.08A 4q0dA-3n6oA:
undetectable		 4q0dA-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.08A 4q0dB-3n6oA:
undetectable		 4q0dB-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 12 ALA A 492
LEU A 530
SER A 624
ILE A 571
LEU A 604
 None
 1.07A 4q0dE-3n6oA:
undetectable		 4q0dE-3n6oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 11 SER A 399
GLY A 402
ASP A 457
PHE A 460
GLU A 361
 None
 1.37A 4xt7A-3n6oA:
undetectable		 4xt7A-3n6oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		3 / 3 GLU A 631
HIS A 496
ASP A 577
 None
 0.79A 5c0oG-3n6oA:
undetectable		 5c0oG-3n6oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR
(Legionella
pneumophila) 		5 / 9 ASN A 437
ALA A 413
ILE A 475
GLY A 470
ILE A 365
 None
 1.28A 5kr2A-3n6oA:
undetectable		 5kr2A-3n6oA:
14.88