SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_A_ESTA351_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	6 / 12	GLY A 178 GLY A 173 TYR A 199 LEU A 224 SER A 225 VAL A 223	SO4 A 1 (-3.2A) None None None None None	1.30A	1fduA-3n70A: undetectable	1fduA-3n70A: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_C_ESTC353_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	5 / 12	GLY A 178 GLY A 173 TYR A 199 SER A 225 VAL A 223	SO4 A 1 (-3.2A) None None None None	1.05A	1fduC-3n70A: undetectable	1fduC-3n70A: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RL8_A_RITA9001_1 (PROTEASE RETROPEPSIN)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	5 / 12	GLY A 182 ALA A 183 GLY A 190 ALA A 168 ILE A 252	None	0.92A	1rl8A-3n70A: undetectable	1rl8A-3n70A: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDB_A_NPSA1591_1 (SERUM ALBUMIN)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	4 / 8	ILE A 281 LEU A 162 TYR A 155 ARG A 179	None None None SO4 A 1 (-4.4A)	0.95A	2vdbA-3n70A: undetectable	2vdbA-3n70A: 13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_0 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	5 / 12	ALA A 174 GLY A 173 GLY A 255 LEU A 171 LEU A 284	None	0.97A	5c0oH-3n70A: undetectable	5c0oH-3n70A: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G44_A_YTZA1512_1 (NUCLEAR RECEPTOR ROR-GAMMA)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	5 / 9	LEU A 162 ALA A 183 VAL A 223 ARG A 250 ALA A 168	None	1.31A	5g44A-3n70A: undetectable	5g44A-3n70A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_A_CVIA608_0 (ACETYLCHOLINESTERASE)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	4 / 7	THR A 203 LEU A 202 VAL A 223 TYR A 199	None	0.97A	5ov9A-3n70A: undetectable	5ov9A-3n70A: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_B_CVIB602_0 (ACETYLCHOLINESTERASE)	3n70	TRANSPORT ACTIVATOR (Escherichia coli)	4 / 8	THR A 203 LEU A 202 VAL A 223 TYR A 199	None	0.97A	5ov9B-3n70A: undetectable	5ov9B-3n70A: 16.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FDU_A_ESTA351_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","3n70","TRANSPORT ACTIVATOR","Escherichia coli",6,"GLY A 178;GLY A 173;TYR A 199;LEU A 224;SER A 225;VAL A 223","SO4 A   1 (-3.2A);None;None;None;None;None","1.30A","1fduA-3n70A:undetectable","1fduA-3n70A:20.06"],["1FDU_C_ESTC353_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","3n70","TRANSPORT ACTIVATOR","Escherichia coli",5,"GLY A 178;GLY A 173;TYR A 199;SER A 225;VAL A 223","SO4 A   1 (-3.2A);None;None;None;None","1.05A","1fduC-3n70A:undetectable","1fduC-3n70A:20.06"],["1RL8_A_RITA9001_1","PROTEASE RETROPEPSIN","3n70","TRANSPORT ACTIVATOR","Escherichia coli",5,"GLY A 182;ALA A 183;GLY A 190;ALA A 168;ILE A 252","None","0.92A","1rl8A-3n70A:undetectable","1rl8A-3n70A:22.07"],["2VDB_A_NPSA1591_1","SERUM ALBUMIN","3n70","TRANSPORT ACTIVATOR","Escherichia coli",4,"ILE A 281;LEU A 162;TYR A 155;ARG A 179","None;None;None;SO4 A   1 (-4.4A)","0.95A","2vdbA-3n70A:undetectable","2vdbA-3n70A:13.01"],["5C0O_H_SAMH301_0","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","3n70","TRANSPORT ACTIVATOR","Escherichia coli",5,"ALA A 174;GLY A 173;GLY A 255;LEU A 171;LEU A 284","None","0.97A","5c0oH-3n70A:undetectable","5c0oH-3n70A:21.20"],["5G44_A_YTZA1512_1","NUCLEAR RECEPTOR ROR-GAMMA","3n70","TRANSPORT ACTIVATOR","Escherichia coli",5,"LEU A 162;ALA A 183;VAL A 223;ARG A 250;ALA A 168","None","1.31A","5g44A-3n70A:undetectable","5g44A-3n70A:18.15"],["5OV9_A_CVIA608_0","ACETYLCHOLINESTERASE","3n70","TRANSPORT ACTIVATOR","Escherichia coli",4,"THR A 203;LEU A 202;VAL A 223;TYR A 199","None","0.97A","5ov9A-3n70A:undetectable","5ov9A-3n70A:16.24"],["5OV9_B_CVIB602_0","ACETYLCHOLINESTERASE","3n70","TRANSPORT ACTIVATOR","Escherichia coli",4,"THR A 203;LEU A 202;VAL A 223;TYR A 199","None","0.97A","5ov9B-3n70A:undetectable","5ov9B-3n70A:16.24"]]