SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		3 / 3 ALA A1001
VAL A 950
TRP A 949
 None
 0.90A 1c4dA-3n7kA:
undetectable
1c4dB-3n7kA:
undetectable		 1c4dA-3n7kA:
8.80
1c4dB-3n7kA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 10 ASP A1212
SER A1234
ASN A1240
ILE A1241
GLY A1243
 None
 1.27A 1mehA-3n7kA:
undetectable		 1mehA-3n7kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 8 GLY A1285
ALA A1228
ASN A1116
ILE A1117
 None
 0.75A 2dtjA-3n7kA:
undetectable
2dtjB-3n7kA:
undetectable		 2dtjA-3n7kA:
18.03
2dtjB-3n7kA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		3 / 3 GLY A 888
ASP A 885
SER A 875
 None
 0.52A 3brfA-3n7kA:
7.3		 3brfA-3n7kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		3 / 3 ARG A1161
ASP A1166
ASP A1159
 None
 0.83A 3jayA-3n7kA:
undetectable		 3jayA-3n7kA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 12 GLY A 967
MET A 934
VAL A 930
ILE A 970
PHE A 979
 None
 1.35A 3mnoA-3n7kA:
undetectable		 3mnoA-3n7kA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 12 GLY A 967
MET A 934
VAL A 930
ILE A 970
PHE A 979
 None
 1.33A 3mnpA-3n7kA:
undetectable		 3mnpA-3n7kA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 7 ASP A1212
PHE A1216
VAL A1268
ILE A1201
 None
 0.95A 3pglA-3n7kA:
undetectable		 3pglA-3n7kA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 8 VAL A 893
VAL A 921
ILE A1070
PHE A1048
 None
 0.73A 3warA-3n7kA:
undetectable		 3warA-3n7kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 9 ILE A 946
PHE A1008
PHE A 993
TRP A 949
VAL A 950
 None
 1.31A 4afgA-3n7kA:
undetectable
4afgE-3n7kA:
undetectable		 4afgA-3n7kA:
19.49
4afgE-3n7kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 7 PHE A 938
ASN A1015
ILE A1040
PHE A1042
 None
 0.80A 4ejjA-3n7kA:
undetectable		 4ejjA-3n7kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 7 PHE A 938
ASN A1015
ILE A1040
PHE A1042
 None
 0.83A 4ejjD-3n7kA:
undetectable		 4ejjD-3n7kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 8 ILE A 940
ILE A 944
PHE A1009
GLY A1026
 None
 0.96A 4hdlA-3n7kA:
undetectable		 4hdlA-3n7kA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 11 LEU A 911
ILE A1053
GLY A 971
ILE A 970
ILE A1050
 None
 1.21A 5kr2B-3n7kA:
undetectable		 5kr2B-3n7kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 12 VAL A 978
LEU A 977
ILE A 940
MET A1020
LEU A 981
 None
 1.16A 5og9B-3n7kA:
undetectable		 5og9B-3n7kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		5 / 12 ILE A 929
VAL A 899
LEU A 901
GLY A 888
LEU A 874
 None
 1.25A 6a7pA-3n7kA:
undetectable		 6a7pA-3n7kA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 6 PHE A 905
ARG A1161
ASN A1104
ASP A1105
 None
 1.20A 6dhbA-3n7kA:
undetectable		 6dhbA-3n7kA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3n7k BOTULINUM NEUROTOXIN
TYPE C1
(Clostridium
botulinum) 		4 / 6 ARG A 945
LYS A1006
VAL A1287
PRO A1288
 None
 1.47A 6fgdA-3n7kA:
undetectable		 6fgdA-3n7kA:
22.49