SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 8 THR A 233
GLY A 138
GLY A 103
GLY A 135
 None
 0.71A 1d0vA-3n7tA:
3.7		 1d0vA-3n7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 8 THR A 233
GLY A 138
GLY A 103
GLY A 135
 None
 0.71A 1jhaA-3n7tA:
3.4		 1jhaA-3n7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 12 GLY A 166
ALA A 145
GLY A 171
HIS A 111
LEU A 186
 None
 1.10A 1kiaC-3n7tA:
3.7		 1kiaC-3n7tA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 7 PHE A  45
LEU A   4
VAL A 241
ILE A 234
 None
 0.88A 1t87B-3n7tA:
undetectable		 1t87B-3n7tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 12 LEU A  10
GLY A 110
PHE A  29
VAL A 140
ALA A 139
 None
 1.01A 1tlsA-3n7tA:
undetectable		 1tlsA-3n7tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 10 THR A 229
GLY A 138
VAL A 107
GLU A  32
ILE A 137
 None
 1.25A 3uayA-3n7tA:
undetectable		 3uayA-3n7tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 7 ASP A 116
THR A  13
THR A  55
SER A  51
 None
 1.26A 5b6iA-3n7tA:
undetectable		 5b6iA-3n7tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 6 ASP A 116
THR A  13
THR A  55
SER A  51
 None
 1.27A 5b6iB-3n7tA:
2.6		 5b6iB-3n7tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 5 LEU A  28
PHE A  83
LEU A  10
TRP A  58
 None
 1.26A 5m10A-3n7tA:
3.6		 5m10A-3n7tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 10 ALA A  94
ILE A 150
ILE A 137
VAL A 107
ALA A  50
 None
 1.04A 5nukA-3n7tA:
undetectable		 5nukA-3n7tA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 9 LEU A 114
VAL A 107
MET A 146
GLY A 110
THR A  26
 None
 1.50A 5w5vA-3n7tA:
undetectable		 5w5vA-3n7tA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		5 / 11 PHE A  29
GLY A 109
GLY A 220
GLN A 224
THR A 227
 None
None
None
None
EDO  A 244 (-3.7A)
 1.21A 5x19G-3n7tA:
0.0
5x19N-3n7tA:
0.0
5x19O-3n7tA:
0.0		 5x19G-3n7tA:
16.39
5x19N-3n7tA:
17.67
5x19O-3n7tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3n7t MACROPHAGE BINDING
PROTEIN
(Coccidioides
immitis) 		4 / 8 GLY A 134
LEU A 104
GLY A 103
LEU A   4
 None
 0.82A 6mdqA-3n7tA:
1.2		 6mdqA-3n7tA:
16.24