SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		5 / 11 LEU A  57
LEU A  58
ALA A  55
LEU A 370
ILE A 338
 None
 1.29A 1g50A-3n8uA:
undetectable		 1g50A-3n8uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 5 ASP A 346
SER A 345
ASN A  53
SER A 341
 None
 1.06A 1kiaB-3n8uA:
undetectable		 1kiaB-3n8uA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		3 / 3 SER A 162
THR A 264
PHE A 313
 None
 0.59A 2x91A-3n8uA:
1.7		 2x91A-3n8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		3 / 3 SER A 308
GLU A 137
ASP A 119
 None
MG  A   1 ( 4.6A)
None
 0.79A 2zulA-3n8uA:
undetectable		 2zulA-3n8uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 6 ALA A  55
LEU A  58
ALA A 301
THR A 300
 None
 0.82A 3b6hA-3n8uA:
1.4		 3b6hA-3n8uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 6 ALA A  55
LEU A  58
ALA A 301
THR A 300
 None
 0.75A 3b6hB-3n8uA:
1.5		 3b6hB-3n8uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 8 ALA A 217
CYH A 221
THR A 149
ILE A 152
 None
 0.80A 3bpxA-3n8uA:
1.0
3bpxB-3n8uA:
0.7		 3bpxA-3n8uA:
16.16
3bpxB-3n8uA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		3 / 3 SER A 308
GLU A 137
ASP A 119
 None
MG  A   1 ( 4.6A)
None
 0.80A 3dmhA-3n8uA:
undetectable		 3dmhA-3n8uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		5 / 11 ASP A 258
PHE A  83
LEU A 172
LEU A 249
PHE A 311
 None
 1.16A 3ko0A-3n8uA:
undetectable
3ko0B-3n8uA:
undetectable
3ko0I-3n8uA:
undetectable
3ko0J-3n8uA:
undetectable		 3ko0A-3n8uA:
14.11
3ko0B-3n8uA:
14.11
3ko0I-3n8uA:
14.11
3ko0J-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		5 / 12 LEU A 249
PHE A 311
LEU A 172
PHE A  83
ASP A 258
 None
 1.14A 3ko0K-3n8uA:
undetectable
3ko0L-3n8uA:
undetectable
3ko0S-3n8uA:
undetectable
3ko0T-3n8uA:
undetectable		 3ko0K-3n8uA:
14.11
3ko0L-3n8uA:
14.11
3ko0S-3n8uA:
14.11
3ko0T-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		5 / 12 LEU A 249
PHE A 311
LEU A 172
ASP A 258
PHE A  83
 None
 1.12A 3ko0M-3n8uA:
undetectable
3ko0N-3n8uA:
undetectable
3ko0O-3n8uA:
undetectable
3ko0P-3n8uA:
undetectable		 3ko0M-3n8uA:
14.11
3ko0N-3n8uA:
14.11
3ko0O-3n8uA:
14.11
3ko0P-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 5 ASP A 164
SER A 162
SER A 171
GLY A 165
 None
 1.11A 3rxhA-3n8uA:
undetectable		 3rxhA-3n8uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 6 SER A  78
GLU A  77
VAL A 257
THR A 254
 None
 1.32A 4lnxA-3n8uA:
undetectable		 4lnxA-3n8uA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 5 TYR A 153
ASN A 157
TYR A 160
ILE A 191
 None
 1.47A 4o0oA-3n8uA:
undetectable		 4o0oA-3n8uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		5 / 12 GLY A 366
MET A 325
ASN A 324
ALA A  62
ASN A 272
 None
 1.24A 5kc4A-3n8uA:
1.8		 5kc4A-3n8uA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3n8u IMELYSIN PEPTIDASE
(Bacteroides
ovatus) 		4 / 8 LEU A 249
VAL A 252
VAL A  98
ILE A 176
 None
 0.78A 5y9mA-3n8uA:
undetectable		 5y9mA-3n8uA:
12.18