SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 PHE A 172
LEU A  41
VAL A 138
ILE A  58
ILE A  56
 None
 0.96A 1epbA-3n92A:
undetectable		 1epbA-3n92A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 PHE A 172
LEU A  41
VAL A 138
ILE A  58
ILE A  56
 None
 0.96A 1epbB-3n92A:
undetectable		 1epbB-3n92A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 PRO A 149
ASP A 412
ASN A 410
TYR A 147
 None
 1.40A 1hpkA-3n92A:
undetectable		 1hpkA-3n92A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 TYR A 480
HIS A  19
HIS A 488
ARG A 519
VAL A 548
 None
 1.46A 1ituB-3n92A:
5.4		 1ituB-3n92A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 ASP A 520
ARG A 519
GLU A 518
ASP A 491
GLU A 459
 None
 1.34A 1nd4A-3n92A:
0.0		 1nd4A-3n92A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 ASP A 520
ARG A 519
GLU A 518
ASP A 491
GLU A 459
 None
 1.36A 1nd4B-3n92A:
0.0		 1nd4B-3n92A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ALA A 143
LEU A 148
THR A 140
ILE A 179
LEU A 209
 None
 1.09A 1rg7A-3n92A:
undetectable		 1rg7A-3n92A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 LEU A 130
GLY A 134
ILE A  56
PHE A  44
LEU A  47
 None
 1.10A 2f8dB-3n92A:
undetectable		 2f8dB-3n92A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 LEU A 499
VAL A 503
LYS A 504
ILE A 453
 None
 0.66A 2piwA-3n92A:
undetectable		 2piwA-3n92A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 PHE A  54
TYR A 135
ARG A 388
THR A   6
 None
 1.49A 2x2iB-3n92A:
undetectable		 2x2iB-3n92A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ALA A 257
GLY A 253
LEU A 386
PRO A 248
PHE A 259
 None
 1.05A 2y7hB-3n92A:
undetectable		 2y7hB-3n92A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ALA A 351
PRO A 352
GLY A 266
THR A 265
LEU A 237
 None
 1.04A 2zifB-3n92A:
undetectable		 2zifB-3n92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ILE A 123
LEU A 127
LEU A 130
VAL A 136
ILE A  56
 None
 1.00A 3adxB-3n92A:
undetectable		 3adxB-3n92A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		3 / 3 TYR A 353
TYR A 276
GLY A 266
 None
 0.73A 3eteB-3n92A:
undetectable
3eteD-3n92A:
undetectable
3eteF-3n92A:
undetectable		 3eteB-3n92A:
22.42
3eteD-3n92A:
22.42
3eteF-3n92A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		3 / 3 GLU A 432
GLU A 464
TRP A 425
 None
 1.31A 3hrdA-3n92A:
undetectable
3hrdE-3n92A:
undetectable
3hrdF-3n92A:
undetectable		 3hrdA-3n92A:
22.74
3hrdE-3n92A:
22.74
3hrdF-3n92A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 HIS A 488
LEU A 151
GLN A 160
VAL A 526
 None
 1.03A 3jwqC-3n92A:
undetectable		 3jwqC-3n92A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 GLU A 137
VAL A 350
PHE A 259
TYR A 216
PHE A 218
 None
 1.35A 3r6wA-3n92A:
undetectable
3r6wB-3n92A:
undetectable		 3r6wA-3n92A:
18.03
3r6wB-3n92A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 HIS A  12
GLU A 183
ASP A 467
PRO A 182
 None
 1.07A 4apjA-3n92A:
undetectable
4apjP-3n92A:
undetectable		 4apjA-3n92A:
21.74
4apjP-3n92A:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 HIS A  12
GLU A 183
ASP A 467
SER A 466
 None
 1.29A 4apjA-3n92A:
undetectable
4apjP-3n92A:
undetectable		 4apjA-3n92A:
21.74
4apjP-3n92A:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 PRO A 248
GLY A 347
ILE A 349
PHE A 259
LEU A 386
 None
 1.43A 4kotA-3n92A:
undetectable		 4kotA-3n92A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ALA A 185
LEU A 148
ALA A 142
ILE A 179
ILE A 161
 None
 1.05A 4o2bB-3n92A:
undetectable		 4o2bB-3n92A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 5 LEU A 461
ALA A 431
VAL A 439
ILE A 438
 None
 0.88A 4xe3B-3n92A:
undetectable		 4xe3B-3n92A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		3 / 3 HIS A 339
LYS A 342
PHE A 343
 None
 1.22A 5klaA-3n92A:
undetectable		 5klaA-3n92A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ALA A 185
LEU A 148
ALA A 142
ILE A 179
ILE A 161
 None
 1.00A 5mioB-3n92A:
undetectable		 5mioB-3n92A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 LEU A 306
TRP A 297
TYR A  97
SER A 292
 None
 1.32A 5umwA-3n92A:
undetectable
5umwF-3n92A:
undetectable		 5umwA-3n92A:
9.58
5umwF-3n92A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 ALA A 162
ILE A 161
GLY A 178
SER A 141
GLY A 164
 None
 1.23A 6awoA-3n92A:
1.8		 6awoA-3n92A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3n92 ALPHA-AMYLASE, GH57
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 ALA A 162
ILE A 161
GLY A 178
SER A 141
GLY A 164
 None
 1.24A 6awqA-3n92A:
undetectable		 6awqA-3n92A:
20.23