SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLU A -67
GLU A -70
ALA A -72
LEU A -73
GLU A -74
 None
 1.46A 1a29A-3n94A:
undetectable		 1a29A-3n94A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A -86
GLY A -59
ALA A-239
ILE A-240
 None
 0.80A 2aohB-3n94A:
undetectable		 2aohB-3n94A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A -45
ILE A-240
VAL A-251
LEU A-272
ILE A-269
 None
 1.25A 2h42A-3n94A:
undetectable		 2h42A-3n94A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A -86
ILE A-240
VAL A-251
LEU A-272
ILE A-269
 None
 0.92A 2h42C-3n94A:
undetectable		 2h42C-3n94A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A-255
LEU A -63
ASP A -61
GLU A-237
 None
None
None
MAL  A5044 (-2.9A)
 1.05A 2zw9A-3n94A:
undetectable		 2zw9A-3n94A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A-156
THR A-155
ALA A  -2
THR A  -3
ILE A   0
 None
 1.20A 3a35A-3n94A:
undetectable		 3a35A-3n94A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A-156
THR A-155
ALA A  -2
THR A  -3
ILE A   0
 None
 1.21A 3a35B-3n94A:
undetectable		 3a35B-3n94A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A-238
GLY A -48
PRO A-119
LYS A -43
 None
 0.66A 3bjwC-3n94A:
undetectable		 3bjwC-3n94A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A-238
GLY A -48
PRO A-119
LYS A -43
 None
 0.89A 3bjwA-3n94A:
undetectable		 3bjwA-3n94A:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A-334
LYS A-333
LYS A-306
GLU A-304
GLU A-303
ALA A-285
ASP A-283
ARG A-282
GLU A-237
TRP A-118
 MAL  A5044 (-3.1A)
MAL  A5044 (-2.7A)
None
None
None
MAL  A5044 (-3.3A)
MAL  A5044 (-2.8A)
MAL  A5044 (-3.8A)
MAL  A5044 (-2.9A)
MAL  A5044 ( 4.5A)
 0.77A 3jyrA-3n94A:
57.3		 3jyrA-3n94A:
79.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A-334
LYS A-333
LYS A-306
GLU A-304
GLU A-303
ALA A-285
ASP A-283
GLU A-237
PRO A-194
TRP A-118
 MAL  A5044 (-3.1A)
MAL  A5044 (-2.7A)
None
None
None
MAL  A5044 (-3.3A)
MAL  A5044 (-2.8A)
MAL  A5044 (-2.9A)
MAL  A5044 (-3.3A)
MAL  A5044 ( 4.5A)
 0.50A 3jyrA-3n94A:
57.3		 3jyrA-3n94A:
79.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A-336
TRP A-286
GLU A-195
TYR A-193
MET A -18
TRP A  -8
 MAL  A5044 ( 4.7A)
MAL  A5044 (-4.4A)
MAL  A5044 (-3.7A)
MAL  A5044 (-3.8A)
MAL  A5044 ( 4.2A)
MAL  A5044 (-3.6A)
 0.24A 3jyrA-3n94A:
57.3		 3jyrA-3n94A:
79.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A-152
LEU A-188
GLY A-161
ALA A-160
LEU A  13
 None
 0.98A 3n8yB-3n94A:
undetectable		 3n8yB-3n94A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A-192
GLY A -48
LEU A -49
GLU A-237
ALA A-117
 MAL  A5044 ( 4.9A)
None
None
MAL  A5044 (-2.9A)
None
 0.81A 3tbgB-3n94A:
undetectable		 3tbgB-3n94A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A-192
GLY A -48
LEU A -49
GLU A-237
ALA A-117
 MAL  A5044 ( 4.9A)
None
None
MAL  A5044 (-2.9A)
None
 0.79A 3tbgD-3n94A:
undetectable		 3tbgD-3n94A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A-117
TYR A-331
TYR A-138
ASN A-114
GLY A-120
 None
 1.38A 3vwqA-3n94A:
undetectable		 3vwqA-3n94A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A-117
ASP A -52
TYR A-138
ASN A-114
GLY A-120
 None
 1.32A 3vwrA-3n94A:
undetectable		 3vwrA-3n94A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A-275
PHE A  24
PRO A-300
GLN A-299
 None
 1.20A 4j7uD-3n94A:
undetectable		 4j7uD-3n94A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A -82
ALA A-243
LEU A-328
VAL A-325
ILE A-289
 None
 1.09A 4m2xG-3n94A:
undetectable		 4m2xG-3n94A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A -81
ALA A-297
GLY A-292
ASP A-334
 None
None
None
MAL  A5044 (-3.1A)
 1.00A 4n48A-3n94A:
undetectable		 4n48A-3n94A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A -84
ALA A-243
LEU A-245
LEU A -86
VAL A -87
 None
 1.14A 4or0B-3n94A:
undetectable		 4or0B-3n94A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A-272
GLY A -83
ALA A -84
SER A -85
 None
 0.92A 5f1aB-3n94A:
undetectable		 5f1aB-3n94A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 116
ASN A  85
ASP A  89
 None
 0.80A 5vopA-3n94A:
undetectable		 5vopA-3n94A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 116
ASN A  85
ASP A  89
 None
 0.85A 5vopB-3n94A:
undetectable		 5vopB-3n94A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A  -6
ALA A -10
GLY A-182
ALA A-160
PHE A-179
VAL A-167
 None
 1.41A 5w4zA-3n94A:
undetectable		 5w4zA-3n94A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A -88
LYS A -51
ASP A -52
VAL A -55
ILE A-337
 None
 1.03A 5wz1A-3n94A:
undetectable		 5wz1A-3n94A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A -88
LYS A -51
ASP A -52
VAL A -55
ILE A-337
 None
 1.04A 5wz1G-3n94A:
undetectable		 5wz1G-3n94A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A-209
LEU A-226
ASN A-224
ILE A-216
LYS A-221
 None
 1.16A 5xiwD-3n94A:
undetectable		 5xiwD-3n94A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A-193
ASN A-121
LEU A-235
 MAL  A5044 (-3.8A)
None
None
 0.81A 6b58A-3n94A:
undetectable		 6b58A-3n94A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A-215
GLU A-218
PRO A -94
ALA A-185
PRO A-189
 None
 1.46A 6bm5A-3n94A:
undetectable		 6bm5A-3n94A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A  17
ALA A  16
ALA A-186
GLY A-182
ALA A-160
 None
 1.07A 6hwdH-3n94A:
undetectable
6hwdI-3n94A:
undetectable		 6hwdH-3n94A:
10.58
6hwdI-3n94A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A  17
ALA A  16
ALA A-186
GLY A-182
ALA A-160
 None
 1.07A 6hwdV-3n94A:
undetectable		 6hwdV-3n94A:
10.58