SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n9v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 10 LEU A 448
VAL A 482
TYR A 415
TRP A 444
LEU A 527
 None
 1.39A 1fkoA-3n9vA:
undetectable		 1fkoA-3n9vA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 LEU A 478
GLY A 446
TYR A 450
GLU A 493
 None
 1.04A 1jlfA-3n9vA:
undetectable
1jlfB-3n9vA:
undetectable		 1jlfA-3n9vA:
19.40
1jlfB-3n9vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A 350
VAL A 299
GLY A 300
VAL A 274
 None
 0.85A 1t88A-3n9vA:
undetectable		 1t88A-3n9vA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 ARG A 451
HIS A 549
ASP A 524
ALA A 403
 None
 0.87A 2rk8A-3n9vA:
undetectable		 2rk8A-3n9vA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 9 ILE A 418
ASP A 447
LEU A 448
GLY A 446
ASN A 398
 None
 1.38A 4eb4C-3n9vA:
undetectable		 4eb4C-3n9vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 9 PHE A 491
ASP A 447
LEU A 448
GLY A 446
ASN A 398
 None
 1.36A 4eb4C-3n9vA:
undetectable		 4eb4C-3n9vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_A_VIBA501_1
(THIAMINE
PYRIDINYLASE I)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 10 THR A 486
GLU A 493
TYR A 450
ASP A 476
LEU A 496
 None
 1.15A 4kysA-3n9vA:
0.0		 4kysA-3n9vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 11 THR A 486
GLU A 493
TYR A 450
ASP A 476
LEU A 496
 None
 1.14A 4kysB-3n9vA:
undetectable		 4kysB-3n9vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 3 LEU A 544
LYS A 545
THR A 546
 None
 0.63A 4lj0A-3n9vA:
undetectable		 4lj0A-3n9vA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 411
GLU A 407
ARG A 451
 None
 0.92A 4mwvA-3n9vA:
undetectable		 4mwvA-3n9vA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A 544
PHE A 301
VAL A 299
GLY A 300
LEU A 287
 None
 1.17A 4ot2A-3n9vA:
undetectable		 4ot2A-3n9vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 GLU A 453
ASP A 476
ARG A 525
ARG A 451
 None
 1.19A 4uhxA-3n9vA:
undetectable		 4uhxA-3n9vA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 11 LEU A 283
VAL A 299
TYR A 272
GLY A 270
TRP A 322
 None
 1.44A 5hbmA-3n9vA:
undetectable		 5hbmA-3n9vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 418
ASP A 447
GLY A 446
ASN A 398
ALA A 403
 None
 1.13A 5x66A-3n9vA:
undetectable
5x66B-3n9vA:
undetectable		 5x66A-3n9vA:
19.88
5x66B-3n9vA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 9 ILE A 418
ASP A 447
GLY A 446
ASN A 398
ALA A 403
 None
 1.16A 5x66C-3n9vA:
undetectable		 5x66C-3n9vA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 10 ILE A 418
ASP A 447
GLY A 446
ASN A 398
ALA A 403
 None
 1.15A 5x66D-3n9vA:
undetectable		 5x66D-3n9vA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 ASN A 449
HIS A 400
GLY A 276
ASN A 273
 None
None
None
MG  A  61 ( 4.8A)
 1.10A 5x7pA-3n9vA:
undetectable		 5x7pA-3n9vA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 ASP A 524
GLY A 378
ASN A 398
VAL A 383
 None
 0.98A 6giqL-3n9vA:
undetectable
6giqP-3n9vA:
undetectable
6giqT-3n9vA:
undetectable		 6giqL-3n9vA:
21.47
6giqP-3n9vA:
22.40
6giqT-3n9vA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 12 PHE A 311
GLY A 346
LEU A 304
ASN A 379
ILE A 373
 None
 1.11A 6mhtA-3n9vA:
2.7		 6mhtA-3n9vA:
24.11