SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3na0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 THR A 438
GLU A 383
THR A 384
HIS A 338
 None
 1.36A 1d4fD-3na0A:
undetectable		 1d4fD-3na0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 392
THR A 393
GLN A 395
ILE A 123
 2DC  A 602 ( 4.7A)
2DC  A 602 ( 4.7A)
2DC  A 602 (-3.0A)
None
 1.49A 1ss4A-3na0A:
0.9		 1ss4A-3na0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 273
ALA A 325
ILE A 123
HIS A 130
PHE A 274
 None
2DC  A 602 ( 3.8A)
None
None
None
 1.35A 1y0xX-3na0A:
2.1		 1y0xX-3na0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 135
SER A 275
TYR A 129
 None
 0.74A 2q2hA-3na0A:
undetectable
2q2hB-3na0A:
undetectable		 2q2hA-3na0A:
16.06
2q2hB-3na0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLN A 336
ARG A 185
LEU A 202
ASP A 201
 None
 1.03A 2qqcB-3na0A:
undetectable
2qqcC-3na0A:
undetectable		 2qqcB-3na0A:
12.95
2qqcC-3na0A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 202
ASP A 201
GLN A 336
ARG A 185
 None
 1.03A 2qqcA-3na0A:
undetectable
2qqcF-3na0A:
undetectable		 2qqcA-3na0A:
7.53
2qqcF-3na0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 202
ASP A 201
GLN A 336
ARG A 185
 None
 1.02A 2qqcG-3na0A:
undetectable
2qqcJ-3na0A:
undetectable		 2qqcG-3na0A:
7.53
2qqcJ-3na0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 202
ASP A 201
GLN A 336
ARG A 185
 None
 1.01A 2qqcI-3na0A:
undetectable
2qqcL-3na0A:
undetectable		 2qqcI-3na0A:
7.53
2qqcL-3na0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 TYR A 303
LEU A 306
LEU A 288
HIS A 295
 None
 1.46A 2x7hB-3na0A:
undetectable		 2x7hB-3na0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A  89
GLU A  91
THR A  69
 None
 0.98A 2y7hB-3na0A:
undetectable		 2y7hB-3na0A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 100
GLU A  91
THR A  69
 None
 0.94A 2y7hB-3na0A:
undetectable		 2y7hB-3na0A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
ADRENODOXIN,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASP C  72
ILE A 467
GLY A 464
LEU A 168
THR A 331
 None
HEM  A 601 ( 4.9A)
HEM  A 601 (-3.5A)
None
HEM  A 601 ( 4.7A)
 1.18A 3eeyE-3na0C:
undetectable		 3eeyE-3na0C:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
ADRENODOXIN,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASP C  72
ILE A 467
GLY A 464
LEU A 168
THR A 331
 None
HEM  A 601 ( 4.9A)
HEM  A 601 (-3.5A)
None
HEM  A 601 ( 4.7A)
 1.14A 3eeyF-3na0C:
undetectable		 3eeyF-3na0C:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 THR A 438
GLU A 383
THR A 384
HIS A 338
 None
 1.23A 3glqB-3na0A:
undetectable		 3glqB-3na0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 234
ILE A 123
TRP A 126
MET A 240
 None
 1.31A 3welA-3na0A:
undetectable		 3welA-3na0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 234
ILE A 123
TRP A 270
MET A 240
 None
 1.43A 3weoA-3na0A:
undetectable		 3weoA-3na0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 441
ASP A 436
ARG A 439
TRP A 440
 None
 1.50A 4cpzA-3na0A:
undetectable		 4cpzA-3na0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO A  54
ASN A  81
HIS A  77
 None
 0.73A 4ma3H-3na0A:
undetectable
4ma3L-3na0A:
undetectable		 4ma3H-3na0A:
16.77
4ma3L-3na0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 441
ASP A 436
ARG A 439
TRP A 440
 None
 1.49A 4mwrA-3na0A:
undetectable		 4mwrA-3na0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A 475
HIS A 338
LEU A 352
PRO A 437
 None
 1.24A 4o8zA-3na0A:
undetectable		 4o8zA-3na0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 173
ASP A 297
ARG A 299
GLY A 300
 None
 0.60A 5bs8A-3na0A:
1.7
5bs8C-3na0A:
1.7
5bs8D-3na0A:
undetectable		 5bs8A-3na0A:
22.28
5bs8C-3na0A:
22.28
5bs8D-3na0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 173
ASP A 297
ARG A 299
GLY A 300
 None
 0.57A 5btdA-3na0A:
1.7
5btdC-3na0A:
1.7
5btdD-3na0A:
undetectable		 5btdA-3na0A:
22.28
5btdC-3na0A:
22.28
5btdD-3na0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 173
ASP A 297
ARG A 299
GLY A 300
 None
 0.51A 5btgA-3na0A:
1.7
5btgC-3na0A:
1.7
5btgD-3na0A:
undetectable		 5btgA-3na0A:
22.28
5btgC-3na0A:
22.28
5btgD-3na0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CLT_C_ACRC1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASN A  61
GLU A  91
PRO A  87
TYR A  85
GLY A  86
 None
 1.34A 5cltC-3na0A:
0.1		 5cltC-3na0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 380
ALA A 379
HIS A 338
LEU A 352
 None
 1.15A 5dzkb-3na0A:
2.0
5dzkp-3na0A:
undetectable		 5dzkb-3na0A:
19.16
5dzkp-3na0A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 380
ALA A 379
HIS A 338
LEU A 377
 None
 1.29A 5dzkb-3na0A:
2.0
5dzkp-3na0A:
undetectable		 5dzkb-3na0A:
19.16
5dzkp-3na0A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 380
ALA A 379
HIS A 338
LEU A 377
 None
 1.32A 5dzkc-3na0A:
undetectable
5dzkq-3na0A:
undetectable		 5dzkc-3na0A:
19.16
5dzkq-3na0A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 506
GLN A 488
GLY A 196
SER A 195
THR A 510
 None
 1.03A 5hfjB-3na0A:
undetectable		 5hfjB-3na0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A 380
ILE A 381
LEU A 377
LEU A 352
 None
 0.95A 5u4sA-3na0A:
undetectable		 5u4sA-3na0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 380
ILE A 381
LEU A 377
LEU A 352
 None
 0.95A 5u4sB-3na0A:
undetectable		 5u4sB-3na0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 507
PHE A 511
PHE A 475
GLY A 196
PHE A 205
 None
 1.31A 5v5zA-3na0A:
17.8		 5v5zA-3na0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 474
ILE A 198
LEU A 339
HIS A 338
 None
 0.98A 5vkqA-3na0A:
undetectable
5vkqB-3na0A:
undetectable		 5vkqA-3na0A:
14.09
5vkqB-3na0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 474
ILE A 198
LEU A 339
HIS A 338
 None
 0.99A 5vkqB-3na0A:
undetectable
5vkqC-3na0A:
undetectable		 5vkqB-3na0A:
14.09
5vkqC-3na0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 474
ILE A 198
LEU A 339
HIS A 338
 None
 0.97A 5vkqC-3na0A:
undetectable
5vkqD-3na0A:
undetectable		 5vkqC-3na0A:
14.09
5vkqD-3na0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 474
ILE A 198
LEU A 339
HIS A 338
 None
 0.96A 5vkqA-3na0A:
undetectable
5vkqD-3na0A:
undetectable		 5vkqA-3na0A:
14.09
5vkqD-3na0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 171
MET A 367
THR A 369
LEU A 371
 None
 1.07A 5x1fA-3na0A:
1.2
5x1fJ-3na0A:
undetectable		 5x1fA-3na0A:
21.08
5x1fJ-3na0A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0B-3na0A:
undetectable		 6ew0B-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0D-3na0A:
undetectable		 6ew0D-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0F-3na0A:
undetectable		 6ew0F-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0G-3na0A:
undetectable		 6ew0G-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0H-3na0A:
undetectable		 6ew0H-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0I-3na0A:
undetectable		 6ew0I-3na0A:
11.52