SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3na6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 4 ILE A   6
LEU A  52
VAL A  87
ILE A  40
 None
 0.86A 1fm6D-3na6A:
undetectable		 1fm6D-3na6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 8 VAL A 248
SER A 247
ASN A 178
LYS A 226
 None
 1.15A 1hwiB-3na6A:
undetectable		 1hwiB-3na6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 6 LEU A  52
LEU A 134
PRO A 135
MET A 136
 None
 1.01A 1hz4A-3na6A:
undetectable		 1hz4A-3na6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 3 GLY A  59
ASP A  60
ASN A  57
 None
 0.64A 1vq1A-3na6A:
undetectable		 1vq1A-3na6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 3 ASP A 151
VAL A 324
PRO A 253
 None
 0.67A 2avvA-3na6A:
undetectable		 2avvA-3na6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 3 GLU A 209
HIS A  58
GLU A  61
 None
CL  A 331 (-4.5A)
None
 0.84A 2x45B-3na6A:
undetectable		 2x45B-3na6A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 3 GLU A 209
HIS A  58
GLU A  61
 None
CL  A 331 (-4.5A)
None
 0.87A 2x45C-3na6A:
undetectable		 2x45C-3na6A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 10 ILE A  43
THR A  41
THR A  75
VAL A  80
ILE A 237
 None
 1.36A 3kpbD-3na6A:
undetectable		 3kpbD-3na6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 6 PHE A  90
TYR A 194
THR A  54
VAL A  87
 None
 1.04A 3lb3A-3na6A:
undetectable		 3lb3A-3na6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 6 PHE A  90
TYR A 194
THR A  54
VAL A  87
 None
 1.10A 3lb3B-3na6A:
undetectable		 3lb3B-3na6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 326
GLY A 305
LEU A 307
THR A 249
LEU A 250
 None
 0.99A 3mteB-3na6A:
undetectable		 3mteB-3na6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A  84
PHE A 235
VAL A 141
ALA A  67
PHE A 143
 None
 1.42A 3nhxA-3na6A:
undetectable		 3nhxA-3na6A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 326
GLY A 305
LEU A 307
THR A 249
LEU A 250
 None
 0.94A 3p2kA-3na6A:
undetectable		 3p2kA-3na6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 326
GLY A 305
LEU A 307
THR A 249
LEU A 250
 None
 1.09A 3p2kB-3na6A:
undetectable		 3p2kB-3na6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 232
THR A  41
ILE A  10
VAL A  80
TYR A 128
 None
 1.15A 3sp9A-3na6A:
undetectable		 3sp9A-3na6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 232
THR A  41
ILE A  10
VAL A  80
TYR A 128
 None
 1.15A 3sp9B-3na6A:
undetectable		 3sp9B-3na6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 12 TYR A 194
LEU A 205
VAL A 204
VAL A 231
HIS A 234
 None
 1.41A 3vt7A-3na6A:
undetectable		 3vt7A-3na6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		5 / 9 ASN A  57
PHE A 129
GLY A  55
TYR A 194
ASP A 142
 None
 1.27A 3ztvA-3na6A:
undetectable		 3ztvA-3na6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 3 GLU A 187
ASP A 189
ASP A 254
 None
 0.68A 4gc9A-3na6A:
undetectable		 4gc9A-3na6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 6 MET A 201
ILE A  38
ILE A  40
VAL A  87
 None
 1.00A 4olmA-3na6A:
undetectable		 4olmA-3na6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		3 / 4 ARG A 291
GLY A 293
GLU A 294
 None
 0.63A 4z2dB-3na6A:
undetectable
4z2dC-3na6A:
3.5		 4z2dB-3na6A:
20.27
4z2dC-3na6A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 5 THR A 149
GLY A 213
GLU A 209
HIS A 144
 None
 1.18A 5c0oH-3na6A:
undetectable		 5c0oH-3na6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLY A 119
GLY A 115
PHE A 113
LEU A 109
 None
 0.78A 5izfA-3na6A:
undetectable		 5izfA-3na6A:
19.25