SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 ILE A 153
ALA A 154
ALA A 158
THR A 162
ARG A 199
 None
 1.07A 2fr3A-3navA:
undetectable		 2fr3A-3navA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 ILE A 241
GLY A  26
ILE A  36
ILE A  80
ALA A  71
 None
 1.20A 3uj7A-3navA:
undetectable		 3uj7A-3navA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 11 GLY A  98
ALA A 143
VAL A 126
MET A 101
ILE A  85
 None
 1.30A 4j4vA-3navA:
undetectable		 4j4vA-3navA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 11 GLY A  98
ALA A 143
VAL A 126
MET A 101
ILE A  85
 None
 1.25A 4j4vD-3navA:
undetectable
4j4vE-3navA:
undetectable		 4j4vD-3navA:
23.43
4j4vE-3navA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 ALA A 158
THR A 162
LEU A 163
THR A 174
PRO A 192
 None
 1.21A 4ypmA-3navA:
undetectable		 4ypmA-3navA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 ALA A 208
THR A 174
LEU A 176
GLY A 227
ALA A 223
 None
 0.92A 4ypmA-3navA:
undetectable		 4ypmA-3navA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 SER A 136
PHE A 152
ILE A 148
ALA A 143
VAL A 126
 None
 1.03A 5n0sB-3navA:
undetectable		 5n0sB-3navA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 12 GLY A  51
LEU A 100
GLY A  98
ILE A  80
VAL A 126
 None
EDO  A 601 (-4.7A)
None
None
None
 1.07A 6mhtA-3navA:
undetectable		 6mhtA-3navA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Vibrio
cholerae) 		5 / 10 PHE A 152
ILE A 128
ASN A 104
LEU A 105
LEU A 100
 None
None
None
None
EDO  A 601 (-4.7A)
 1.26A 6r2eC-3navA:
undetectable		 6r2eC-3navA:
20.87