SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3naw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 406
PHE A 410
SER A 363
ILE A 364
LEU A 386
 None
 1.20A 1dreA-3nawA:
undetectable		 1dreA-3nawA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 454
LEU A 425
HIS A 413
LEU A 365
 None
 0.78A 1errA-3nawA:
undetectable		 1errA-3nawA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 406
PHE A 410
SER A 363
ILE A 364
LEU A 386
 None
 1.17A 1rh3A-3nawA:
undetectable		 1rh3A-3nawA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 185
SER A 236
LEU A 211
LEU A 208
 None
 1.17A 1yajA-3nawA:
undetectable		 1yajA-3nawA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A 670
THR A 726
ILE A 668
GLN A 682
 None
 0.88A 2a8tB-3nawA:
undetectable		 2a8tB-3nawA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 213
LEU A 208
SER A 177
LEU A 181
LEU A 211
 None
 1.00A 2ceoA-3nawA:
undetectable		 2ceoA-3nawA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 492
GLU A 489
GLN A 488
 GOL  A 783 (-4.3A)
GOL  A 783 ( 4.4A)
SO4  A   1 (-4.1A)
 0.97A 2p16A-3nawA:
undetectable		 2p16A-3nawA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 740
PHE A 773
GLY A 690
GLY A 691
 None
 0.68A 2qx4A-3nawA:
undetectable
2qx4B-3nawA:
undetectable		 2qx4A-3nawA:
17.43
2qx4B-3nawA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 8 PHE A 731
ILE A 740
GLY A 690
GLY A 691
 None
 0.50A 2qx4A-3nawA:
undetectable
2qx4B-3nawA:
undetectable		 2qx4A-3nawA:
17.43
2qx4B-3nawA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 6 PHE A 731
ILE A 740
GLY A 690
GLY A 691
 None
 0.49A 2qx6A-3nawA:
undetectable
2qx6B-3nawA:
undetectable		 2qx6A-3nawA:
17.43
2qx6B-3nawA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 433
SER A 411
LEU A 406
 None
 0.70A 2w1bA-3nawA:
undetectable		 2w1bA-3nawA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 689
ILE A 711
TRP A 658
TYR A 696
 None
 1.22A 2zlcA-3nawA:
undetectable		 2zlcA-3nawA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 9 GLN A 745
ASN A 717
LEU A 761
TYR A 737
ILE A 720
 None
 1.25A 3claA-3nawA:
undetectable		 3claA-3nawA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 CYH A 429
PHE A 432
PHE A 433
 None
 0.57A 3cr5X-3nawA:
undetectable		 3cr5X-3nawA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 406
PHE A 410
SER A 363
ILE A 364
LEU A 386
 None
 1.18A 3ia4C-3nawA:
undetectable		 3ia4C-3nawA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 406
PHE A 410
SER A 363
ILE A 364
LEU A 386
 None
 1.21A 3ia4D-3nawA:
undetectable		 3ia4D-3nawA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 744
GLY A 703
THR A 704
CYH A 753
LEU A 757
 None
 0.85A 3okxA-3nawA:
undetectable		 3okxA-3nawA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 744
GLY A 703
THR A 704
CYH A 753
LEU A 757
 None
 0.87A 3okxB-3nawA:
undetectable		 3okxB-3nawA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 11 VAL A 665
PHE A 607
GLY A 690
GLY A 691
ILE A 720
 None
 1.22A 3owxA-3nawA:
undetectable
3owxB-3nawA:
undetectable		 3owxA-3nawA:
17.43
3owxB-3nawA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 568
TYR A 599
LEU A 550
 None
 0.79A 3sueB-3nawA:
undetectable		 3sueB-3nawA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 5 GLY A 514
PRO A 522
ASN A 533
TYR A 495
 None
 1.28A 3u8qA-3nawA:
undetectable		 3u8qA-3nawA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 744
LEU A 655
GLY A 657
ILE A 711
ALA A 648
 None
 0.96A 3uwlB-3nawA:
undetectable		 3uwlB-3nawA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 744
LEU A 655
GLY A 657
ILE A 711
ALA A 648
 None
 0.95A 3uwlD-3nawA:
undetectable		 3uwlD-3nawA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 6 PHE A 272
LEU A 271
GLU A 273
SER A 275
 None
 1.40A 3vlnA-3nawA:
2.3		 3vlnA-3nawA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 494
PHE A 460
PRO A 464
ALA A 466
 None
 1.40A 3vm4A-3nawA:
undetectable		 3vm4A-3nawA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 615
ILE A 711
ILE A 611
LEU A 719
LEU A 744
 None
 1.05A 3vw1B-3nawA:
undetectable		 3vw1B-3nawA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 615
ILE A 711
TYR A 715
ILE A 611
LEU A 719
 None
 1.34A 3vw1B-3nawA:
undetectable		 3vw1B-3nawA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 LYS A 330
THR A 333
ILE A 309
 None
 0.77A 4e0fB-3nawA:
undetectable		 4e0fB-3nawA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 337
GLY A 338
LEU A 386
PRO A 311
LEU A 343
 None
 1.08A 4fzvA-3nawA:
undetectable		 4fzvA-3nawA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 4 TYR A 737
THR A 726
VAL A 730
ILE A 720
 None
 1.40A 4jx1F-3nawA:
undetectable		 4jx1F-3nawA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 8 SER A 391
LEU A 351
LEU A 354
VAL A 402
 None
 0.96A 4oj4A-3nawA:
undetectable		 4oj4A-3nawA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 223
ALA A 241
SER A 236
LEU A 233
LEU A 208
 None
 1.23A 4qztC-3nawA:
undetectable		 4qztC-3nawA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 6 ALA A 723
ILE A 611
ILE A 720
VAL A 692
 None
 0.77A 4r21A-3nawA:
undetectable		 4r21A-3nawA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 8 LEU A 208
LEU A 185
LEU A 218
LEU A 228
ALA A 226
 None
 1.05A 4z90A-3nawA:
0.0
4z90B-3nawA:
1.8
4z90C-3nawA:
1.8
4z90D-3nawA:
1.8
4z90E-3nawA:
1.8		 4z90A-3nawA:
20.13
4z90B-3nawA:
20.13
4z90C-3nawA:
20.13
4z90D-3nawA:
20.13
4z90E-3nawA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 8 LEU A 218
LEU A 228
ALA A 226
LEU A 208
LEU A 185
 None
 1.08A 4z90A-3nawA:
0.0
4z90B-3nawA:
1.8
4z90C-3nawA:
1.8
4z90D-3nawA:
1.8
4z90E-3nawA:
1.8		 4z90A-3nawA:
20.13
4z90B-3nawA:
20.13
4z90C-3nawA:
20.13
4z90D-3nawA:
20.13
4z90E-3nawA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 740
VAL A 756
GLY A 691
THR A 752
THR A 762
 None
 1.20A 5byjA-3nawA:
undetectable		 5byjA-3nawA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 TRP A 781
LEU A 629
ILE A 611
THR A 758
LEU A 689
 None
 1.32A 5ienA-3nawA:
undetectable		 5ienA-3nawA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		4 / 7 ILE A 436
PHE A 433
ASP A 408
SER A 411
 None
 1.33A 5nr3A-3nawA:
undetectable		 5nr3A-3nawA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 686
LEU A 689
GLY A 690
GLY A 691
LEU A 660
 None
 1.01A 5uc1A-3nawA:
undetectable		 5uc1A-3nawA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 686
LEU A 689
GLY A 690
GLY A 691
LEU A 660
 None
 1.03A 5uc1B-3nawA:
undetectable		 5uc1B-3nawA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3naw SECRETED EFFECTOR
PROTEIN
(Escherichia
coli) 		3 / 3 ILE A 341
THR A 333
PRO A 311
 None
 0.52A 6ncsA-3nawA:
undetectable		 6ncsA-3nawA:
19.02