SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP B  59
VAL B 102
TRP B 135
 None
 0.89A 1c4dA-3nbhB:
undetectable
1c4dB-3nbhB:
undetectable		 1c4dA-3nbhB:
6.02
1c4dB-3nbhB:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		5 / 11 LEU A 608
LEU A 517
LEU A 553
VAL A 605
ILE A 530
 None
 1.03A 1ee2A-3nbhA:
undetectable		 1ee2A-3nbhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		5 / 11 LEU A 608
LEU A 517
LEU A 553
VAL A 605
ILE A 530
 None
 1.05A 1ee2B-3nbhA:
undetectable		 1ee2B-3nbhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP B  59
THR A 538
TYR A 493
 None
 1.24A 2a3aA-3nbhB:
undetectable		 2a3aA-3nbhB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP B  59
THR A 538
TYR A 493
 None
 1.21A 2a3aB-3nbhB:
undetectable		 2a3aB-3nbhB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP B  59
THR A 538
TYR A 493
 None
 1.24A 2a3bA-3nbhB:
undetectable		 2a3bA-3nbhB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A 511
ASP A 587
CYH B  95
 None
 1.32A 2br4F-3nbhA:
undetectable		 2br4F-3nbhA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B  17
TYR A 540
PRO B  18
 None
 1.12A 2j9cC-3nbhB:
undetectable		 2j9cC-3nbhB:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		5 / 10 ALA A 603
VAL A 534
ALA A 607
LEU A 588
PHE A 545
 None
 1.17A 3fl9F-3nbhA:
undetectable		 3fl9F-3nbhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		4 / 6 SER B  20
TYR A 540
VAL A 515
THR A 538
 None
 1.08A 3tneA-3nbhB:
undetectable		 3tneA-3nbhB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		3 / 3 SER A 488
PHE A 491
LYS A 509
 None
 0.78A 3u88A-3nbhA:
undetectable		 3u88A-3nbhA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		5 / 12 LEU B  30
LEU B  86
VAL B 104
VAL B 102
MET B  60
 None
 1.00A 4y0qA-3nbhB:
undetectable		 4y0qA-3nbhB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2
(Homo
sapiens) 		6 / 12 VAL B 139
VAL B  58
GLY B 106
ALA B 119
PHE B  81
GLU B  28
 None
 1.32A 6bqgA-3nbhB:
undetectable		 6bqgA-3nbhB:
18.12