SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		3 / 3 ALA A  16
VAL A  20
TRP A  18
 None
 0.80A 1bdwA-3nbiA:
undetectable
1bdwB-3nbiA:
undetectable		 1bdwA-3nbiA:
7.63
1bdwB-3nbiA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		5 / 12 ILE A  31
ILE A   6
GLN A  45
MET A  48
GLU A  28
 None
 1.39A 1ki7B-3nbiA:
undetectable		 1ki7B-3nbiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		3 / 3 LEU A 157
VAL A  95
ARG A 133
 None
 0.63A 3b0wB-3nbiA:
undetectable		 3b0wB-3nbiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		4 / 6 ASP A  71
LEU A  74
ASP A 141
LEU A  87
 None
 1.26A 3bj8C-3nbiA:
undetectable
3bj8D-3nbiA:
undetectable		 3bj8C-3nbiA:
22.36
3bj8D-3nbiA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		3 / 3 THR A 140
ASP A  60
GLU A 200
 None
 0.68A 3qowA-3nbiA:
undetectable		 3qowA-3nbiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		4 / 4 GLY A 142
LEU A  81
PHE A 175
ILE A  73
 None
 0.95A 4xv2A-3nbiA:
undetectable		 4xv2A-3nbiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		3 / 3 THR A 140
ASP A  60
GLU A 200
 None
 0.79A 5fa8A-3nbiA:
undetectable		 5fa8A-3nbiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
(Homo
sapiens) 		5 / 9 LEU A 157
VAL A 187
SER A 174
LEU A 180
ILE A 169
 None
 1.29A 6fdyU-3nbiA:
0.5		 6fdyU-3nbiA:
20.20