SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 1.01A 1pxxC-3nbmA:
undetectable		 1pxxC-3nbmA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 10 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 1.02A 1pxxD-3nbmA:
undetectable		 1pxxD-3nbmA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 10 TYR A 538
GLY A 491
GLY A 466
THR A 467
ALA A 469
 None
 1.13A 2ej3B-3nbmA:
undetectable		 2ej3B-3nbmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 11 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.96A 3pghB-3nbmA:
undetectable		 3pghB-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.95A 3pghC-3nbmA:
undetectable		 3pghC-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.97A 3pghD-3nbmA:
undetectable		 3pghD-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		3 / 3 TYR A 493
ASP A 522
ASP A 498
 None
 0.79A 4a6eA-3nbmA:
undetectable		 4a6eA-3nbmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.98A 4coxC-3nbmA:
undetectable		 4coxC-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 1.09A 4otyB-3nbmA:
undetectable		 4otyB-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		3 / 4 ARG A 534
GLY A 535
GLU A 537
 None
 0.65A 4z2dB-3nbmA:
undetectable
4z2dC-3nbmA:
3.3		 4z2dB-3nbmA:
12.90
4z2dC-3nbmA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS
(Streptococcus
pneumoniae) 		5 / 12 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 1.08A 5kirA-3nbmA:
undetectable		 5kirA-3nbmA:
11.90