SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 10 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.33A 1a52A-3nc3A:
2.3		 1a52A-3nc3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 10 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.34A 1a52B-3nc3A:
2.5		 1a52B-3nc3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 9 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.22A 1ereA-3nc3A:
undetectable		 1ereA-3nc3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 10 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.34A 1qkuA-3nc3A:
2.6		 1qkuA-3nc3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 10 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.35A 1qkuB-3nc3A:
2.6		 1qkuB-3nc3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 10 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.35A 1qkuC-3nc3A:
2.7		 1qkuC-3nc3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 SER A 159
GLU A 236
LEU A 244
GLY A 389
ALA A 386
 None
 1.20A 2kceA-3nc3A:
undetectable		 2kceA-3nc3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 THR A 392
ALA A 233
ALA A  68
VAL A 161
GLY A 160
 None
HEM  A 406 (-3.5A)
None
None
None
 1.08A 2ve3B-3nc3A:
15.5		 2ve3B-3nc3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 ASN A 111
LEU A 115
VAL A 139
VAL A 366
GLU A 113
 None
 1.20A 2vn0A-3nc3A:
30.9		 2vn0A-3nc3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 LEU A 379
ILE A 377
LEU A 371
MET A 256
PRO A 395
 None
 1.06A 2ygpA-3nc3A:
undetectable		 2ygpA-3nc3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 PHE A  15
SER A  37
ASP A  39
ILE A 303
THR A 302
 None
 1.18A 3iv6A-3nc3A:
undetectable		 3iv6A-3nc3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		4 / 8 PHE A 324
LEU A 249
ILE A 246
THR A 241
 None
None
None
HEM  A 406 (-3.5A)
 0.81A 4em2A-3nc3A:
undetectable		 4em2A-3nc3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		4 / 4 LEU A 116
LEU A 371
GLN A 110
GLU A 362
 None
None
None
HEM  A 406 ( 4.6A)
 1.24A 4i41A-3nc3A:
undetectable		 4i41A-3nc3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 12 VAL A 400
GLY A 132
SER A 397
LEU A 242
LEU A 115
 None
 0.95A 4qdjA-3nc3A:
undetectable		 4qdjA-3nc3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		4 / 5 TYR A 276
LYS A 277
PRO A 278
GLU A 387
 None
MG  A 409 (-2.6A)
None
MG  A 409 ( 4.9A)
 1.38A 4w5tA-3nc3A:
undetectable		 4w5tA-3nc3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		5 / 9 SER A 397
ALA A 243
SER A 125
LEU A 399
VAL A 400
 None
 1.32A 4z69A-3nc3A:
4.2		 4z69A-3nc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		4 / 4 LEU A 189
ILE A 154
ARG A 196
TYR A 188
 None
 1.39A 4zzbA-3nc3A:
0.0		 4zzbA-3nc3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3nc3 CYTOCHROME P450 CYPX
(Bacillus
subtilis) 		3 / 3 ASP A 314
VAL A  49
LEU A 344
 None
 0.55A 5e5jB-3nc3A:
undetectable		 5e5jB-3nc3A:
13.85