SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 ALA A 300
ILE A 295
LEU A 166
VAL A 165
ILE A 305
 None
 0.97A 1df7A-3ndaA:
undetectable		 1df7A-3ndaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 272
PHE A 356
PHE A 358
LEU A 277
TYR A 226
 None
 1.07A 1drfA-3ndaA:
undetectable		 1drfA-3ndaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 11 PHE A 180
LEU A 277
VAL A 374
PHE A 358
VAL A 321
 None
 1.24A 1q23J-3ndaA:
undetectable		 1q23J-3ndaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 9 ALA A  10
ASN A  11
LEU A   7
PHE A  45
GLY A  42
 None
 1.01A 1ru9H-3ndaA:
undetectable
1ru9L-3ndaA:
0.7		 1ru9H-3ndaA:
19.51
1ru9L-3ndaA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 10 ALA A  10
ASN A  11
LEU A   7
PHE A  45
GLY A  42
 None
 1.02A 1ruaH-3ndaA:
undetectable
1ruaL-3ndaA:
undetectable		 1ruaH-3ndaA:
19.51
1ruaL-3ndaA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.13A 2bm9A-3ndaA:
undetectable		 2bm9A-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 272
GLU A 326
GLY A 327
ASN A 324
ALA A 330
 None
 1.01A 2bm9B-3ndaA:
undetectable		 2bm9B-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.08A 2bm9D-3ndaA:
undetectable		 2bm9D-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.05A 2br4A-3ndaA:
undetectable		 2br4A-3ndaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.07A 2br4D-3ndaA:
undetectable		 2br4D-3ndaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.10A 2br4F-3ndaA:
undetectable		 2br4F-3ndaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 236
LEU A 357
VAL A 371
LEU A  19
ARG A  20
 None
 1.07A 2bxfA-3ndaA:
undetectable		 2bxfA-3ndaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 ALA A  40
GLY A  42
THR A 334
SER A  36
GLY A 291
 None
 1.09A 2hw2A-3ndaA:
undetectable		 2hw2A-3ndaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 9 PHE A 275
LEU A 277
ASN A  29
GLN A 373
LEU A 377
 None
 1.36A 2ok6B-3ndaA:
0.0
2ok6D-3ndaA:
0.0		 2ok6B-3ndaA:
20.63
2ok6D-3ndaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 10 PHE A 275
LEU A 277
ASN A  29
GLN A 373
LEU A 377
 None
 1.35A 2ok6A-3ndaA:
undetectable
2ok6H-3ndaA:
undetectable		 2ok6A-3ndaA:
20.63
2ok6H-3ndaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A 287
PRO A 286
LEU A 290
 None
 0.58A 2po7B-3ndaA:
undetectable		 2po7B-3ndaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 10 SER A  36
ILE A 170
LEU A 224
THR A 232
GLY A 372
 None
 1.13A 2v0mA-3ndaA:
undetectable		 2v0mA-3ndaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 11 LEU A 302
ALA A  46
LEU A 114
LEU A 166
ILE A 100
 None
 1.13A 3frbX-3ndaA:
undetectable		 3frbX-3ndaA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nda SERPIN-2
(Ixodes
ricinus) 		4 / 5 LEU A  92
TYR A 226
ILE A 360
ALA A 330
 None
 0.93A 3n8yB-3ndaA:
undetectable		 3n8yB-3ndaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3nda SERPIN-2
(Ixodes
ricinus) 		4 / 8 ILE A 100
ILE A 338
LEU A 310
ILE A 305
 None
 0.90A 4dtaB-3ndaA:
undetectable		 4dtaB-3ndaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 272
PHE A 356
PHE A 358
ASN A  29
TYR A 226
 None
 1.08A 4kebB-3ndaA:
undetectable		 4kebB-3ndaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3nda SERPIN-2
(Ixodes
ricinus) 		4 / 6 VAL A 336
VAL A 312
ILE A 295
LEU A  60
 None
 0.99A 4l1wB-3ndaA:
undetectable		 4l1wB-3ndaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 THR A 242
GLY A 193
ASN A 192
GLN A 373
ASN A 241
 None
 1.37A 4pooB-3ndaA:
undetectable		 4pooB-3ndaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 ALA A  10
GLY A  59
ALA A  40
MET A  41
GLY A  42
 None
 1.04A 4r29A-3ndaA:
undetectable		 4r29A-3ndaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 ALA A  10
GLY A  59
ALA A  40
MET A  41
GLY A  42
 None
 1.00A 4r29C-3ndaA:
undetectable		 4r29C-3ndaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 ALA A  10
GLY A  59
ALA A  40
MET A  41
GLY A  42
 None
 1.01A 4r29D-3ndaA:
undetectable		 4r29D-3ndaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 9 TYR A 259
ILE A 253
PHE A 359
LEU A 247
LEU A 217
 None
 1.33A 4ze0A-3ndaA:
undetectable		 4ze0A-3ndaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 THR A  68
ASP A  69
ALA A  70
 None
 0.08A 5g5gB-3ndaA:
undetectable		 5g5gB-3ndaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3nda SERPIN-2
(Ixodes
ricinus) 		4 / 5 GLY A 308
SER A 303
ARG A  49
GLY A 304
 None
 1.10A 5kprA-3ndaA:
undetectable		 5kprA-3ndaA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 10 PHE A  14
ALA A  21
LEU A  18
GLY A  15
LEU A 158
 None
 1.12A 5oy01-3ndaA:
undetectable
5oy07-3ndaA:
undetectable		 5oy01-3ndaA:
12.96
5oy07-3ndaA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 12 LEU A 247
GLU A 220
VAL A 219
PHE A 190
THR A 202
 None
 1.23A 5xiqD-3ndaA:
undetectable		 5xiqD-3ndaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A  92
THR A   8
ASN A  11
 None
 0.74A 6baaE-3ndaA:
undetectable		 6baaE-3ndaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A  92
THR A   8
ASN A  11
 None
 0.74A 6baaF-3ndaA:
undetectable		 6baaF-3ndaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A  92
THR A   8
ASN A  11
 None
 0.74A 6baaG-3ndaA:
undetectable		 6baaG-3ndaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A  92
THR A   8
ASN A  11
 None
 0.74A 6baaH-3ndaA:
undetectable		 6baaH-3ndaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3nda SERPIN-2
(Ixodes
ricinus) 		5 / 11 ALA A  97
TRP A 141
ASP A  93
ALA A 120
LEU A 114
 None
 1.47A 6dk1B-3ndaA:
undetectable		 6dk1B-3ndaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A   7
ASN A  96
LEU A  83
 None
 0.56A 6exiD-3ndaA:
undetectable		 6exiD-3ndaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 LEU A   7
ASN A 168
LEU A  83
 None
 0.58A 6exiD-3ndaA:
undetectable		 6exiD-3ndaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3nda SERPIN-2
(Ixodes
ricinus) 		3 / 3 THR A 178
ALA A 207
LYS A 267
 None
 0.75A 6fgdA-3ndaA:
undetectable		 6fgdA-3ndaA:
21.44