SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ndc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 4 HIS A 164
LEU A 124
LEU A 228
LEU A 205
 SAH  A 300 (-4.8A)
None
None
None
 1.20A 1a4lD-3ndcA:
undetectable		 1a4lD-3ndcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		5 / 12 LEU A 161
LEU A 223
ALA A 193
ALA A 116
LEU A 135
 None
None
SAH  A 300 (-3.4A)
None
None
 1.30A 1kt5A-3ndcA:
undetectable		 1kt5A-3ndcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 5 GLY A  91
GLN A  93
VAL A 106
SER A  88
 None
 0.98A 1zzuA-3ndcA:
undetectable		 1zzuA-3ndcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		5 / 12 THR A  17
GLY A  82
GLY A 109
LEU A  15
VAL A  37
 None
SAH  A 300 ( 3.8A)
None
None
None
 1.14A 3fzgA-3ndcA:
undetectable		 3fzgA-3ndcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 8 THR A 219
LEU A 221
ALA A 115
ALA A 193
 SAH  A 300 (-4.3A)
SAH  A 300 (-4.4A)
None
SAH  A 300 (-3.4A)
 0.95A 3ns1L-3ndcA:
undetectable		 3ns1L-3ndcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 7 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.77A 3p50A-3ndcA:
undetectable		 3p50A-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 7 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.78A 3p50B-3ndcA:
undetectable		 3p50B-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 7 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.79A 3p50C-3ndcA:
undetectable		 3p50C-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 7 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.78A 3p50D-3ndcA:
undetectable		 3p50D-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 7 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.80A 3p50E-3ndcA:
undetectable		 3p50E-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 6 LEU A  41
ALA A  25
ARG A  21
LEU A  79
 None
 1.10A 3rd0A-3ndcA:
undetectable		 3rd0A-3ndcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		5 / 11 ILE A 222
LEU A 135
LEU A 228
GLY A 225
ALA A 117
 None
 1.27A 4fogD-3ndcA:
undetectable		 4fogD-3ndcA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 8 ALA A  89
GLU A  92
GLN A  93
ILE A  62
 None
 0.75A 4kttB-3ndcA:
undetectable		 4kttB-3ndcA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		5 / 12 ILE A  51
VAL A  76
LEU A  84
GLY A 109
THR A  17
 None
 1.01A 5igtA-3ndcA:
undetectable		 5igtA-3ndcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		3 / 3 VAL A  52
LEU A  84
MET A  90
 None
 0.60A 5ikrA-3ndcA:
undetectable		 5ikrA-3ndcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		5 / 12 LEU A 177
ALA A 155
LEU A 124
ILE A 163
LEU A 228
 None
 1.02A 5ljeA-3ndcA:
undetectable		 5ljeA-3ndcA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 8 THR A 150
LEU A 151
VAL A 224
TYR A 181
 None
 1.29A 5ov9B-3ndcA:
undetectable		 5ov9B-3ndcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Rhodobacter
capsulatus) 		4 / 5 ILE A  86
SER A  85
ALA A 114
LEU A 221
 SAH  A 300 (-4.9A)
None
None
SAH  A 300 (-4.4A)
 0.83A 6dwnA-3ndcA:
undetectable		 6dwnA-3ndcA:
16.67