SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ndp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		4 / 6 CYH A  22
ASP A  88
VAL A  21
HIS A  33
 None
 1.37A 1ekjG-3ndpA:
undetectable
1ekjH-3ndpA:
undetectable		 1ekjG-3ndpA:
21.29
1ekjH-3ndpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		4 / 5 SER A  16
GLY A  12
ASP A 107
ASP A  88
 SO4  A 501 (-3.3A)
None
None
None
 0.98A 2oxtB-3ndpA:
undetectable		 2oxtB-3ndpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		5 / 11 PRO A  14
PRO A  13
GLY A  17
THR A  20
LEU A 138
 SO4  A 501 (-4.4A)
None
SO4  A 501 (-3.0A)
None
None
 1.49A 2uvnB-3ndpA:
undetectable		 2uvnB-3ndpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		4 / 4 ILE A  44
ARG A  92
ILE A  58
THR A  48
 None
None
None
SO4  A 504 (-4.1A)
 1.25A 3ia4C-3ndpA:
2.3		 3ia4C-3ndpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		5 / 12 ALA A  26
PHE A 210
LEU A 108
GLY A  17
PHE A 194
 None
None
None
SO4  A 501 (-3.0A)
None
 1.15A 4kykA-3ndpA:
undetectable
4kykB-3ndpA:
undetectable		 4kykA-3ndpA:
25.21
4kykB-3ndpA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		4 / 5 LEU A  77
LEU A  72
LEU A 100
ASN A  43
 None
 1.14A 4n09B-3ndpA:
4.1		 4n09B-3ndpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		3 / 3 TYR A 136
PRO A 142
LEU A 138
 None
 0.93A 6beoA-3ndpA:
undetectable		 6beoA-3ndpA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3ndp ADENYLATE KINASE
ISOENZYME 4
(Homo
sapiens) 		4 / 6 GLN A  23
HIS A 226
ALA A  26
GLN A  27
 None
 1.43A 6f6jC-3ndpA:
undetectable
6f6jD-3ndpA:
undetectable		 6f6jC-3ndpA:
20.44
6f6jD-3ndpA:
20.44