SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 7 ILE A 104
ARG A 105
PRO A 154
GLY A 138
 None
None
None
CL  A 500 ( 3.7A)
 1.14A 2pnjB-3neaA:
5.1		 2pnjB-3neaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		5 / 10 ILE A 166
ASP A  35
ILE A 170
ILE A   7
PHE A  28
 None
EDO  A 512 (-3.6A)
EDO  A 512 (-4.1A)
None
None
 1.17A 2w9sC-3neaA:
undetectable		 2w9sC-3neaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		5 / 12 ILE A  85
SER A 120
LEU A  10
ILE A  90
MET A   6
 None
 1.26A 2xkwB-3neaA:
undetectable		 2xkwB-3neaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		5 / 12 LEU A  97
GLY A  25
LEU A  10
VAL A 150
ILE A 137
 None
 0.95A 3em6B-3neaA:
undetectable		 3em6B-3neaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 8 SER A 120
GLY A 117
PRO A  65
ASN A  12
 None
 0.95A 3lslA-3neaA:
undetectable
3lslD-3neaA:
undetectable		 3lslA-3neaA:
21.03
3lslD-3neaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 8 PRO A  65
ASN A  12
SER A 120
GLY A 117
 None
 0.85A 3lslA-3neaA:
undetectable
3lslD-3neaA:
undetectable		 3lslA-3neaA:
21.03
3lslD-3neaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		5 / 9 LEU A 131
LEU A 181
ILE A 104
ILE A 166
VAL A  93
 None
 1.26A 3tmzA-3neaA:
undetectable		 3tmzA-3neaA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		8 / 9 HIS A  22
LEU A  97
GLY A 114
HIS A 115
ASN A 116
VAL A 146
VAL A 150
LEU A 151
 EDO  A 511 (-4.6A)
None
None
EDO  A 511 ( 4.5A)
EDO  A 511 ( 4.9A)
None
None
None
 0.40A 4qd3A-3neaA:
33.1		 4qd3A-3neaA:
44.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 6 GLY A 102
GLU A 103
ASP A 163
ASP A 100
 None
None
None
CL  A 500 ( 4.4A)
 0.90A 4uckB-3neaA:
undetectable		 4uckB-3neaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 EDO  A 511 (-4.6A)
None
EDO  A 511 ( 4.5A)
None
 1.45A 5m45A-3neaA:
undetectable		 5m45A-3neaA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 EDO  A 511 (-4.6A)
None
EDO  A 511 ( 4.5A)
None
 1.44A 5m45D-3neaA:
undetectable		 5m45D-3neaA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 EDO  A 511 (-4.6A)
None
EDO  A 511 ( 4.5A)
None
 1.44A 5m45G-3neaA:
0.0		 5m45G-3neaA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nea PEPTIDYL-TRNA
HYDROLASE
(Francisella
tularensis) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 EDO  A 511 (-4.6A)
None
EDO  A 511 ( 4.5A)
None
 1.44A 5m45J-3neaA:
0.0		 5m45J-3neaA:
13.76