SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 GLY A  41
ALA A  35
ASP A   5
ILE A 133
VAL A  13
 None
 0.88A 1k6cB-3necA:
undetectable		 1k6cB-3necA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 7 ALA A  26
ILE A 131
ILE A 124
ASP A 110
PHE A 109
 None
 1.23A 1upfB-3necA:
undetectable		 1upfB-3necA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 GLY A  41
ALA A  35
ASP A   5
ILE A 133
VAL A  13
 None
 0.92A 3el5B-3necA:
undetectable		 3el5B-3necA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 VAL A  77
LEU A 152
THR A 112
ILE A 111
ALA A 155
 None
 0.90A 3mdvB-3necA:
undetectable		 3mdvB-3necA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 9 GLY A  41
ALA A  35
ASP A   5
ILE A 133
VAL A  13
 None
 0.93A 3u7sA-3necA:
undetectable		 3u7sA-3necA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		4 / 6 GLU A  57
GLY A  56
GLY A  59
ASP A  58
 None
 1.03A 5a06D-3necA:
undetectable		 5a06D-3necA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 SER A  71
ALA A  70
GLY A  90
HIS A  50
ILE A  88
 None
 1.12A 5eeuI-3necA:
undetectable
5eeuJ-3necA:
undetectable		 5eeuI-3necA:
22.52
5eeuJ-3necA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 SER A  71
ALA A  70
GLY A  90
HIS A  50
ILE A  88
 None
 1.12A 5eevI-3necA:
undetectable
5eevJ-3necA:
undetectable		 5eevI-3necA:
22.52
5eevJ-3necA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		5 / 12 SER A  71
ALA A  70
GLY A  90
HIS A  50
ILE A  88
 None
 1.12A 5eewI-3necA:
undetectable
5eewJ-3necA:
undetectable		 5eewI-3necA:
22.52
5eewJ-3necA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3nec INFLAMMATORY
PROFILIN
(Toxoplasma
gondii) 		4 / 7 VAL A  86
ALA A  82
GLY A  80
VAL A  95
 None
 0.95A 5fpdA-3necA:
undetectable		 5fpdA-3necA:
18.48