SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 1.03A 1sguB-3nekA:
undetectable		 1sguB-3nekA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A 440
ASN A 510
GLY A 508
ALA A 456
TYR A 433
 None
None
GOL  A   1 (-3.8A)
None
None
 1.29A 2axnA-3nekA:
undetectable		 2axnA-3nekA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 410
VAL A 408
GLU A 470
LEU A 469
ARG A 466
 None
 1.34A 2bxfB-3nekA:
undetectable		 2bxfB-3nekA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 0.93A 2f81B-3nekA:
undetectable		 2f81B-3nekA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 391
PHE A 380
LEU A 366
PHE A 363
 None
 0.91A 2vdbA-3nekA:
undetectable		 2vdbA-3nekA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 0.92A 3d1zB-3nekA:
undetectable		 3d1zB-3nekA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 1.05A 3ektD-3nekA:
undetectable		 3ektD-3nekA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 427
ILE A 417
GLY A 416
ALA A 456
VAL A 448
 None
 0.90A 3fpjA-3nekA:
undetectable		 3fpjA-3nekA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 0.98A 3gguA-3nekA:
undetectable		 3gguA-3nekA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 433
ILE A 376
GLY A 508
GLY A 507
PRO A 511
 None
None
GOL  A   1 (-3.8A)
GOL  A   1 ( 4.3A)
None
 1.10A 3jayA-3nekA:
undetectable		 3jayA-3nekA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 1.00A 3ucbA-3nekA:
undetectable		 3ucbA-3nekA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A 377
ILE A 394
ASP A 346
GLY A 345
PHE A 533
 None
 1.33A 4fogA-3nekA:
undetectable		 4fogA-3nekA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 361
ASP A 360
ASP A 355
 None
 0.74A 4gc9A-3nekA:
undetectable		 4gc9A-3nekA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 1.01A 4hlaB-3nekA:
undetectable		 4hlaB-3nekA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 415
GLY A 416
PHE A 444
 GOL  A   1 ( 4.7A)
None
None
None
None
 0.81A 4o3fA-3nekA:
undetectable		 4o3fA-3nekA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 442
PRO A 440
ILE A 431
LEU A 438
 None
 1.24A 5m45A-3nekA:
undetectable		 5m45A-3nekA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 442
PRO A 440
ILE A 431
LEU A 438
 None
 1.29A 5m45D-3nekA:
undetectable		 5m45D-3nekA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 442
PRO A 440
ILE A 431
LEU A 438
 None
 1.24A 5m45G-3nekA:
undetectable		 5m45G-3nekA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 442
PRO A 440
ILE A 431
LEU A 438
 None
 1.32A 5m45J-3nekA:
undetectable		 5m45J-3nekA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 375
GLY A 507
VAL A 513
LEU A 514
ALA A 369
 None
GOL  A   1 ( 4.3A)
None
None
None
 1.15A 5o96E-3nekA:
undetectable
5o96F-3nekA:
undetectable		 5o96E-3nekA:
21.67
5o96F-3nekA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 375
GLY A 508
VAL A 513
LEU A 514
ALA A 369
 None
GOL  A   1 (-3.8A)
None
None
None
 1.12A 5o96E-3nekA:
undetectable
5o96F-3nekA:
undetectable		 5o96E-3nekA:
21.67
5o96F-3nekA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 457
ALA A 456
GLY A 480
ILE A 376
PRO A 511
 GOL  A   1 ( 4.7A)
None
None
None
None
 1.02A 5t2zA-3nekA:
undetectable		 5t2zA-3nekA:
19.91