SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		3 / 3 TRP X 247
ALA X  29
VAL X  32
 None
 0.93A 1c4dA-3nepX:
undetectable
1c4dB-3nepX:
undetectable		 1c4dA-3nepX:
5.58
1c4dB-3nepX:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		3 / 3 ALA X  29
VAL X  32
TRP X 247
 None
 0.92A 1c4dC-3nepX:
undetectable
1c4dD-3nepX:
undetectable		 1c4dC-3nepX:
5.58
1c4dD-3nepX:
5.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 9 GLY X  28
ASP X  53
ILE X  54
ALA X  98
ILE X 119
 None
 0.34A 1cetA-3nepX:
41.9		 1cetA-3nepX:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 9 GLY X  28
ASP X  53
ILE X  54
TYR X  85
ALA X  98
 None
 0.76A 1cetA-3nepX:
41.9		 1cetA-3nepX:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 9 VAL X 120
GLY X 121
ALA X 149
PHE X 155
ILE X 135
 None
 0.99A 1cetA-3nepX:
41.9		 1cetA-3nepX:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 12 ALA X 189
VAL X 166
GLY X 165
THR X 231
VAL X 228
 None
 0.94A 1fb7A-3nepX:
undetectable		 1fb7A-3nepX:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 12 LEU X 190
GLY X 193
PRO X 201
VAL X 322
LEU X 285
 None
 1.05A 1vptA-3nepX:
undetectable		 1vptA-3nepX:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 9 ILE X 227
ILE X 224
VAL X 212
THR X 206
ALA X 189
 None
 1.15A 2m9qA-3nepX:
undetectable		 2m9qA-3nepX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		4 / 8 GLY X 154
PHE X 155
ILE X  96
CYH X  94
 None
 0.81A 3ko0O-3nepX:
undetectable
3ko0Q-3nepX:
undetectable		 3ko0O-3nepX:
13.10
3ko0Q-3nepX:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 11 GLN X  60
PRO X  59
ASP X  53
VAL X 123
ILE X 119
 None
 1.17A 3n23A-3nepX:
undetectable		 3n23A-3nepX:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		4 / 8 THR X  97
LEU X 167
GLY X 251
THR X  35
 None
 0.77A 4c9nA-3nepX:
undetectable		 4c9nA-3nepX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 12 GLY X 233
ALA X 234
GLY X 236
GLY X 235
LEU X 241
 None
 0.96A 4o33A-3nepX:
4.2		 4o33A-3nepX:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 12 GLY X 193
GLY X 194
GLY X 165
ALA X 164
ILE X 268
 None
 0.74A 4rtmA-3nepX:
2.8		 4rtmA-3nepX:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		4 / 7 GLU X 311
LYS X 312
LEU X 315
LEU X 282
 None
 0.64A 4wg0B-3nepX:
undetectable
4wg0C-3nepX:
undetectable		 4wg0B-3nepX:
4.96
4wg0C-3nepX:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		4 / 7 LEU X 282
GLU X 311
LYS X 312
LEU X 315
 None
 0.59A 4wg0L-3nepX:
undetectable
4wg0M-3nepX:
undetectable		 4wg0L-3nepX:
4.96
4wg0M-3nepX:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 11 ILE X 219
ILE X 227
PHE X 175
VAL X 212
THR X 206
 None
 1.02A 5lg3A-3nepX:
undetectable		 5lg3A-3nepX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		4 / 9 ILE X 227
PHE X 175
VAL X 212
THR X 206
 None
 0.96A 5lg3I-3nepX:
undetectable		 5lg3I-3nepX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 12 ILE X 219
ILE X 227
PHE X 175
VAL X 212
THR X 206
 None
 1.03A 5lg3J-3nepX:
undetectable		 5lg3J-3nepX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nep MALATE DEHYDROGENASE
(Salinibacter
ruber) 		5 / 10 VAL X  32
GLY X  33
LEU X 167
ILE X 136
THR X  97
 None
 0.88A 5vm8B-3nepX:
4.8		 5vm8B-3nepX:
22.39