SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3net'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A 399
ALA A 369
GLN A 370
LEU A 461
PHE A 421
 None
 1.21A 1g5yB-3netA:
undetectable		 1g5yB-3netA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  68
PHE A 127
GLY A 129
PHE A  15
 None
 1.17A 1gsfA-3netA:
undetectable		 1gsfA-3netA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  68
PHE A 127
GLY A 129
PHE A  15
 None
 1.17A 1gsfB-3netA:
undetectable		 1gsfB-3netA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  68
PHE A 127
GLY A 129
PHE A  15
 None
 1.17A 1gsfD-3netA:
undetectable		 1gsfD-3netA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 10 THR A 100
ARG A 128
GLN A 142
TYR A 303
GLY A 324
 None
 1.21A 1httA-3netA:
29.5		 1httA-3netA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		7 / 12 THR A 100
ARG A 128
GLN A 142
TYR A 303
GLY A 324
TYR A 327
GLY A 343
 None
 0.93A 1httB-3netA:
29.2		 1httB-3netA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		6 / 12 THR A 100
GLN A 142
TYR A 303
GLY A 324
TYR A 327
GLY A 343
 None
 0.78A 1httC-3netA:
29.6		 1httC-3netA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		6 / 12 THR A 100
ARG A 128
GLN A 142
TYR A 303
GLY A 324
GLY A 343
 None
 1.04A 1httD-3netA:
29.2		 1httD-3netA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 420
ASP A 415
ASP A 439
 None
 0.67A 3jayA-3netA:
undetectable		 3jayA-3netA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 311
VAL A 178
GLU A 309
 None
 0.76A 3v4tA-3netA:
undetectable
3v4tD-3netA:
undetectable		 3v4tA-3netA:
23.63
3v4tD-3netA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		4 / 7 THR A 100
GLY A 324
TYR A 327
GLY A 343
 None
 0.77A 4rdxA-3netA:
27.9		 4rdxA-3netA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A 306
GLY A 343
GLY A 324
ALA A 119
ASP A 158
 None
 0.98A 5c0oF-3netA:
undetectable		 5c0oF-3netA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A 100
ARG A 128
GLN A 142
TYR A 327
GLY A 343
 None
 0.74A 5e3iA-3netA:
27.7		 5e3iA-3netA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		6 / 12 THR A 100
GLN A 142
TYR A 303
GLY A 324
TYR A 327
GLY A 343
 None
 0.75A 5e3iA-3netA:
27.7		 5e3iA-3netA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 11 THR A 100
ARG A 128
GLN A 142
TYR A 327
GLY A 343
 None
 0.71A 5e3iB-3netA:
27.4		 5e3iB-3netA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		6 / 11 THR A 100
GLN A 142
TYR A 303
GLY A 324
TYR A 327
GLY A 343
 None
 0.75A 5e3iB-3netA:
27.4		 5e3iB-3netA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		5 / 11 ASP A 248
SER A 245
VAL A 280
ILE A 277
ILE A 181
 None
 1.20A 5y80A-3netA:
2.1		 5y80A-3netA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3net HISTIDYL-TRNA
SYNTHETASE
(Nostoc
sp.
PCC
7120) 		4 / 7 THR A  32
LEU A  29
ILE A 346
PHE A 169
 None
 0.73A 5zsfA-3netA:
undetectable
5zsfB-3netA:
undetectable		 5zsfA-3netA:
8.60
5zsfB-3netA:
8.60