SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 113
GLY A 110
SER A  99
LEU A 182
LEU A 167
 None
 1.07A 1rjdC-3nf2A:
undetectable		 1rjdC-3nf2A:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 11 SER A 124
LEU A 125
ARG A 137
THR A 218
GLN A 255
 None
 1.02A 1rqjA-3nf2A:
31.5		 1rqjA-3nf2A:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 11 SER A 124
LEU A 125
ARG A 137
THR A 218
GLN A 255
 None
 0.97A 1rqjB-3nf2A:
31.5		 1rqjB-3nf2A:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 134
MET A 131
ASP A 132
ASP A 129
 None
None
SO4  A   3 (-4.2A)
None
 1.47A 1t03A-3nf2A:
undetectable		 1t03A-3nf2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 11 GLY A 110
ALA A 114
ALA A 116
LEU A 167
VAL A  53
 None
 1.14A 1ukbA-3nf2A:
undetectable		 1ukbA-3nf2A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 369
GLY A 251
SER A 226
ALA A 253
ALA A 342
 None
 1.14A 2br4F-3nf2A:
undetectable		 2br4F-3nf2A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 125
ASP A 132
ARG A 137
GLN A 193
LYS A 217
 None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
SO4  A   3 (-2.8A)
 0.87A 2f94F-3nf2A:
26.7		 2f94F-3nf2A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 125
ARG A 137
THR A 218
GLN A 255
LYS A 282
 None
None
None
None
SO4  A   3 (-2.7A)
 1.12A 2o1oB-3nf2A:
24.2		 2o1oB-3nf2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 301
SER A 298
ILE A 329
PRO A 286
GLY A 334
 None
 1.42A 3ik6B-3nf2A:
undetectable
3ik6E-3nf2A:
undetectable		 3ik6B-3nf2A:
19.94
3ik6E-3nf2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 221
VAL A 117
HIS A  72
ALA A  50
LEU A  54
 None
 1.29A 3ozuA-3nf2A:
undetectable		 3ozuA-3nf2A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		6 / 12 GLY A 113
GLY A 233
GLY A 110
THR A 103
GLU A 174
ASP A 357
 None
 1.43A 4ctjA-3nf2A:
undetectable		 4ctjA-3nf2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 324
ALA A 327
ALA A 326
VAL A 287
LEU A 305
 None
 1.11A 4j6dA-3nf2A:
undetectable		 4j6dA-3nf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 324
ALA A 327
ALA A 326
VAL A 287
LEU A 305
 None
 1.11A 4j6dB-3nf2A:
undetectable		 4j6dB-3nf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 11 ALA A 324
ALA A 327
ALA A 326
VAL A 287
LEU A 305
 None
 1.14A 4jbtB-3nf2A:
undetectable		 4jbtB-3nf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 GLU A 244
ARG A 181
ALA A 230
GLY A 229
LEU A 232
 None
 1.35A 4oadA-3nf2A:
undetectable		 4oadA-3nf2A:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		6 / 8 SER A 124
LEU A 125
ASP A 132
ARG A 137
GLN A 193
LYS A 217
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
SO4  A   3 (-2.8A)
 1.01A 4umjA-3nf2A:
29.7		 4umjA-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 9 SER A 124
LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 0.90A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 9 SER A 124
LEU A 125
ASP A 132
ARG A 137
LYS A 217
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 (-2.8A)
 0.96A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 9 SER A 124
LEU A 125
ASP A 132
ARG A 137
THR A 218
 None
None
SO4  A   3 (-4.2A)
None
None
 1.01A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 366
LEU A  95
GLY A 233
LEU A 232
VAL A 117
 None
 1.21A 4wnwA-3nf2A:
undetectable		 4wnwA-3nf2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 10 ALA A 100
VAL A 102
SER A 226
SER A 227
GLY A 229
 None
 1.33A 4xp1A-3nf2A:
0.9		 4xp1A-3nf2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		4 / 4 LEU A 328
LEU A 305
GLY A 302
GLU A 303
 None
 1.16A 5hhjA-3nf2A:
undetectable		 5hhjA-3nf2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 182
ALA A 185
SER A 188
GLY A 247
LEU A 222
 None
 1.19A 5m5cE-3nf2A:
undetectable		 5m5cE-3nf2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		4 / 5 GLY A 215
THR A 218
ASN A 216
LYS A 217
 None
None
None
SO4  A   3 (-2.8A)
 1.18A 5x23A-3nf2A:
undetectable		 5x23A-3nf2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		4 / 7 LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 0.82A 6g31D-3nf2A:
24.5		 6g31D-3nf2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3nf2 PUTATIVE POLYPRENYL
SYNTHETASE
(Streptomyces
coelicolor) 		4 / 6 LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 1.12A 6g31J-3nf2A:
24.8		 6g31J-3nf2A:
14.29