SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ALA A 306
GLU A  81
ALA A 327
THR A 326
 None
 0.88A 1ie4B-3nf4A:
undetectable
1ie4D-3nf4A:
undetectable		 1ie4B-3nf4A:
17.14
1ie4D-3nf4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 SER A 321
ILE A 322
GLU A 367
GLY A 368
 None
None
None
FAD  A 384 ( 4.4A)
 0.84A 1meiA-3nf4A:
undetectable		 1meiA-3nf4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 ALA A  88
VAL A  92
THR A 164
HIS A 165
ALA A 210
 None
None
FAD  A 384 (-4.0A)
None
None
 1.12A 1r55A-3nf4A:
undetectable		 1r55A-3nf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 ALA A 320
ASP A 244
LEU A 243
ILE A 372
ARG A 379
 None
 1.29A 1rb3A-3nf4A:
undetectable		 1rb3A-3nf4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 LYS A 160
GLU A 133
ALA A 216
LEU A 197
 None
 1.02A 1sn0B-3nf4A:
undetectable
1sn0D-3nf4A:
undetectable		 1sn0B-3nf4A:
16.20
1sn0D-3nf4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 306
ALA A 307
LEU A  77
ALA A 320
LEU A  10
 None
 1.02A 2aclA-3nf4A:
undetectable
2aclE-3nf4A:
undetectable		 2aclA-3nf4A:
22.40
2aclE-3nf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 GLY A  56
GLY A 123
GLY A  53
 None
 0.38A 3bogC-3nf4A:
undetectable		 3bogC-3nf4A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 210
HIS A 209
LEU A 208
ALA A  27
LEU A  52
 None
 1.03A 3tm4A-3nf4A:
undetectable		 3tm4A-3nf4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 210
HIS A 209
LEU A 208
ALA A  27
LEU A  52
 None
 1.07A 3tm4B-3nf4A:
undetectable		 3tm4B-3nf4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 174
VAL A 190
PHE A 199
ALA A 169
SER A 130
 None
 1.21A 4evrA-3nf4A:
undetectable		 4evrA-3nf4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 320
ASP A 244
LEU A 243
ILE A 372
ARG A 379
 None
 1.31A 4gh8B-3nf4A:
undetectable		 4gh8B-3nf4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 VAL A 211
TYR A  44
HIS A 165
LEU A  52
 None
 0.98A 4jtrA-3nf4A:
undetectable		 4jtrA-3nf4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 236
ALA A 239
LEU A 131
ILE A 372
GLY A 368
 None
None
FAD  A 384 (-4.3A)
None
FAD  A 384 ( 4.4A)
 1.20A 4pxmB-3nf4A:
undetectable		 4pxmB-3nf4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A 317
SER A 321
PHE A 240
 None
 0.70A 5mugA-3nf4A:
undetectable		 5mugA-3nf4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3nf4 ACYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 ALA A 320
ASP A 244
LEU A 243
ILE A 372
ARG A 379
 None
 1.39A 5z6lA-3nf4A:
undetectable		 5z6lA-3nf4A:
17.81