SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 HIS A  56
ILE A  55
ALA A 132
VAL A 254
 None
 0.93A 1hk1A-3nfbA:
undetectable		 1hk1A-3nfbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 THR A 100
GLN A 205
GLU A 133
GLY A 289
GLY A  77
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
OAE  A 376 ( 4.5A)
OAE  A 376 ( 3.7A)
 1.30A 1httB-3nfbA:
undetectable		 1httB-3nfbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ALA A 259
GLY A 327
ALA A 270
THR A 320
LEU A 261
 None
 1.30A 1jipA-3nfbA:
undetectable		 1jipA-3nfbA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 7 MET A 269
GLN A 265
ALA A 259
PHE A 325
 None
 1.29A 1t9wA-3nfbA:
undetectable		 1t9wA-3nfbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 LEU A 340
GLY A 185
SER A 343
ALA A 335
ALA A 331
 None
 1.12A 2br4A-3nfbA:
undetectable		 2br4A-3nfbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 LEU A 340
GLY A 185
SER A 343
ALA A 335
ALA A 331
 None
 1.13A 2br4D-3nfbA:
undetectable		 2br4D-3nfbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 LEU A 251
GLY A 185
SER A 343
ALA A 335
ALA A 331
 None
 1.12A 2br4F-3nfbA:
undetectable		 2br4F-3nfbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 LEU A 340
GLY A 185
SER A 343
ALA A 335
ALA A 331
 None
 1.14A 2br4F-3nfbA:
undetectable		 2br4F-3nfbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 11 ILE A  21
GLY A  16
THR A  22
ARG A   3
GLY A 201
 None
 1.19A 2fn1B-3nfbA:
undetectable		 2fn1B-3nfbA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 LEU A 266
VAL A 164
VAL A  24
ILE A  55
 None
 1.00A 2hyyA-3nfbA:
undetectable		 2hyyA-3nfbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		3 / 3 VAL A 337
GLU A 333
GLU A 334
 None
 0.79A 2nv4A-3nfbA:
undetectable		 2nv4A-3nfbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 8 ARG A 189
SER A 187
ASP A  23
ALA A 331
 None
 1.02A 2rk8A-3nfbA:
undetectable		 2rk8A-3nfbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ARG A 268
LEU A 309
ILE A 313
ALA A 259
THR A 257
 None
 1.26A 2v0mC-3nfbA:
undetectable		 2v0mC-3nfbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 11 ARG A 268
LEU A 309
ILE A 313
ALA A 259
THR A 257
 None
 1.25A 2v0mD-3nfbA:
undetectable		 2v0mD-3nfbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 8 ALA A  17
GLY A 162
SER A 188
ALA A  20
 None
 0.75A 2vh3B-3nfbA:
undetectable		 2vh3B-3nfbA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 10 ILE A 255
ALA A 331
PHE A 325
LEU A 261
THR A 332
 None
 1.15A 2w3aB-3nfbA:
undetectable		 2w3aB-3nfbA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.15A 3ndvA-3nfbA:
68.2
3ndvB-3nfbA:
68.2		 3ndvA-3nfbA:
100.00
3ndvB-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.15A 3ndvA-3nfbA:
68.2
3ndvB-3nfbA:
68.2		 3ndvA-3nfbA:
100.00
3ndvB-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.14A 3ndvC-3nfbA:
68.1
3ndvD-3nfbA:
68.1		 3ndvC-3nfbA:
100.00
3ndvD-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.14A 3ndvC-3nfbA:
68.1
3ndvD-3nfbA:
68.1		 3ndvC-3nfbA:
100.00
3ndvD-3nfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 7 VAL A 164
GLY A  30
ILE A  54
VAL A 254
 None
 0.84A 3ufnB-3nfbA:
undetectable		 3ufnB-3nfbA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 7 LEU A 156
ALA A  96
VAL A 254
ILE A  54
 None
 0.93A 3wsjB-3nfbA:
undetectable		 3wsjB-3nfbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 GLY A 158
ILE A  55
VAL A 169
VAL A  27
ILE A  21
 None
 0.84A 4q5mA-3nfbA:
undetectable		 4q5mA-3nfbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 11 GLY A 239
ASP A 241
GLY A 227
ILE A 225
VAL A 354
 None
 0.97A 4qgiA-3nfbA:
undetectable		 4qgiA-3nfbA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 5 ARG A  49
GLY A  37
GLY A  46
PRO A  47
 None
 0.92A 4u9uA-3nfbA:
undetectable		 4u9uA-3nfbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 PHE A 291
SER A 288
LEU A 251
LEU A 252
 None
OAE  A 376 (-4.7A)
None
None
 1.15A 5dzke-3nfbA:
undetectable
5dzks-3nfbA:
undetectable		 5dzke-3nfbA:
22.25
5dzks-3nfbA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 11 THR A 100
GLN A 205
GLU A 133
GLY A 289
GLY A  77
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
OAE  A 376 ( 4.5A)
OAE  A 376 ( 3.7A)
 1.29A 5e3iB-3nfbA:
undetectable		 5e3iB-3nfbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
 None
None
OAE  A 376 ( 4.5A)
None
None
 0.95A 5i73A-3nfbA:
undetectable		 5i73A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
 None
None
OAE  A 376 ( 4.5A)
None
None
 0.96A 5i75A-3nfbA:
undetectable		 5i75A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 THR A 100
GLY A  99
GLU A 133
ILE A 184
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
None
 0.95A 5kmfA-3nfbA:
undetectable
5kmfC-3nfbA:
undetectable		 5kmfA-3nfbA:
22.51
5kmfC-3nfbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 7 VAL A  52
ILE A  54
VAL A 131
ALA A  96
 None
 0.69A 5ospA-3nfbA:
undetectable		 5ospA-3nfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 7 VAL A  52
ILE A  54
VAL A 131
ALA A  96
 None
 0.73A 5osrA-3nfbA:
undetectable		 5osrA-3nfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		3 / 3 GLY A 172
VAL A 354
MET A 346
 None
 0.52A 5ycpA-3nfbA:
undetectable		 5ycpA-3nfbA:
11.63