SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		4 / 8 SER A 240
ASN A 238
GLN A 237
LYS A 245
 None
 1.07A 2cmlC-3nfiA:
undetectable		 2cmlC-3nfiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 201
ALA A 334
PHE A 364
ILE A 343
VAL A 198
 None
 1.14A 3n0hA-3nfiA:
undetectable		 3n0hA-3nfiA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 201
PHE A 364
ARG A 365
ILE A 343
VAL A 198
 None
 1.03A 4kfjB-3nfiA:
undetectable		 4kfjB-3nfiA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 361
ALA A 395
LYS A 398
TYR A 202
 None
 1.13A 4lb2A-3nfiA:
undetectable		 4lb2A-3nfiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 265
LEU A 262
LEU A 259
ILE A 336
THR A 251
 None
 1.27A 4mk4A-3nfiA:
undetectable		 4mk4A-3nfiA:
22.19