SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 105
LEU A 106
LEU A  63
LEU A  56
LEU A  85
 None
 1.19A 1errB-3nfqA:
undetectable		 1errB-3nfqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 102
LEU A 106
SER A 119
GLN A  99
LEU A  93
 None
 1.11A 3m7rA-3nfqA:
undetectable		 3m7rA-3nfqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
SER A 131
LEU A  93
 None
 0.60A 3n8xA-3nfqA:
undetectable		 3n8xA-3nfqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.02A 3nt1A-3nfqA:
undetectable		 3nt1A-3nfqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.00A 3nt1B-3nfqA:
undetectable		 3nt1B-3nfqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.06A 3pghA-3nfqA:
undetectable		 3pghA-3nfqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.05A 3pghD-3nfqA:
0.5		 3pghD-3nfqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  18
MET A  25
VAL A 111
LEU A 109
LEU A  14
 None
 1.10A 5iepA-3nfqA:
undetectable		 5iepA-3nfqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.05A 5jvzA-3nfqA:
undetectable		 5jvzA-3nfqA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nfq TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.04A 5jw1A-3nfqA:
undetectable		 5jw1A-3nfqA:
15.02