SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ng0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 443
LEU A 425
LEU A 373
VAL A 437
 None
 0.97A 1jgsA-3ng0A:
0.9		 1jgsA-3ng0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  58
TYR A 449
LYS A 450
 None
 1.01A 1uujB-3ng0A:
undetectable		 1uujB-3ng0A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A 432
GLU A 426
ALA A 424
GLU A 419
LEU A 451
 None
 1.25A 2azqA-3ng0A:
undetectable		 2azqA-3ng0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 MET A  68
ASP A  53
SER A  55
TYR A 103
 None
 1.33A 2bteA-3ng0A:
undetectable		 2bteA-3ng0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 452
ASN A 453
THR A 319
 None
 0.69A 2pymB-3ng0A:
undetectable		 2pymB-3ng0A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 MET A  68
ASP A  53
SER A  55
TYR A 103
 None
 1.27A 2v0gA-3ng0A:
undetectable		 2v0gA-3ng0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ASP A 441
GLY A  59
ILE A  57
PRO A 107
THR A 109
 None
 1.13A 3el5A-3ng0A:
undetectable		 3el5A-3ng0A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 205
PHE A  52
GLY A  54
THR A  27
ILE A  25
 None
 1.48A 3ld6B-3ng0A:
undetectable		 3ld6B-3ng0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 374
ILE A  91
THR A  76
ILE A 226
ILE A 245
 None
 1.07A 3prsA-3ng0A:
undetectable		 3prsA-3ng0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A 372
ASP A 229
ASP A 236
 None
 0.81A 3r24A-3ng0A:
undetectable		 3r24A-3ng0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A 362
LEU A 325
ALA A 310
LEU A 335
 None
 0.84A 3t3zA-3ng0A:
undetectable		 3t3zA-3ng0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A 362
LEU A 325
ALA A 310
LEU A 335
 None
 0.81A 3t3zB-3ng0A:
undetectable		 3t3zB-3ng0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A 362
LEU A 325
ALA A 310
LEU A 335
 None
 0.82A 3t3zD-3ng0A:
undetectable		 3t3zD-3ng0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 272
GLU A 215
ASN A 267
 MN  A 477 (-3.2A)
MN  A 475 (-3.1A)
None
 0.97A 4bupB-3ng0A:
undetectable		 4bupB-3ng0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 313
GLU A 454
LEU A 418
LEU A 422
 None
 1.01A 4iomA-3ng0A:
2.1		 4iomA-3ng0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 133
ILE A 123
PHE A 129
GLY A 385
LEU A 360
 None
 1.16A 5fsaA-3ng0A:
undetectable		 5fsaA-3ng0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 236
ASN A  75
PHE A  24
 None
 0.80A 5jglB-3ng0A:
undetectable		 5jglB-3ng0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A 139
PHE A 138
GLY A 220
GLY A 159
 None
 1.01A 5n9xA-3ng0A:
undetectable		 5n9xA-3ng0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 325
GLY A 268
GLU A 134
GLY A 270
ARG A 363
 None
None
MN  A 475 (-3.6A)
None
MN  A 477 (-3.7A)
 1.21A 5o4yD-3ng0A:
undetectable
5o4yE-3ng0A:
undetectable		 5o4yD-3ng0A:
2.80
5o4yE-3ng0A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 272
GLU A 215
ASN A 267
 MN  A 477 (-3.2A)
MN  A 475 (-3.1A)
None
 0.92A 5wbvA-3ng0A:
undetectable		 5wbvA-3ng0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 272
GLU A 215
ASN A 267
 MN  A 477 (-3.2A)
MN  A 475 (-3.1A)
None
 0.93A 5wbvB-3ng0A:
undetectable		 5wbvB-3ng0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A  77
THR A  76
GLN A   6
VAL A   8
 None
 0.76A 6cduA-3ng0A:
undetectable
6cduE-3ng0A:
undetectable		 6cduA-3ng0A:
21.15
6cduE-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLN A   6
VAL A   8
ALA A  77
THR A  76
 None
 0.84A 6cduB-3ng0A:
undetectable
6cduC-3ng0A:
undetectable		 6cduB-3ng0A:
21.15
6cduC-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLN A   6
VAL A   8
ALA A  77
THR A  76
 None
 0.72A 6cduD-3ng0A:
undetectable
6cduE-3ng0A:
undetectable		 6cduD-3ng0A:
21.15
6cduE-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A  77
THR A  76
GLN A   6
VAL A   8
 None
 0.72A 6cduF-3ng0A:
undetectable
6cduJ-3ng0A:
undetectable		 6cduF-3ng0A:
21.15
6cduJ-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLN A   6
VAL A   8
ALA A  77
THR A  76
 None
 0.72A 6cduH-3ng0A:
undetectable
6cduI-3ng0A:
undetectable		 6cduH-3ng0A:
21.15
6cduI-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3ng0 GLUTAMINE SYNTHETASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  57
TYR A 103
THR A 109
ILE A 110
MET A 239
 None
 1.49A 6j20A-3ng0A:
0.1		 6j20A-3ng0A:
21.58