SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ngf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 PHE A  12
ARG A 210
ASN A   7
 None
 0.74A 1xzxX-3ngfA:
undetectable		 1xzxX-3ngfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 10 GLY A  64
GLU A  70
GLY A  69
ALA A  67
ALA A  68
 None
 1.15A 2ej3B-3ngfA:
undetectable		 2ej3B-3ngfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 MET A 105
GLU A 239
ASN A 241
 None
MN  A 262 (-2.7A)
None
 1.09A 3a27A-3ngfA:
undetectable		 3a27A-3ngfA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 ASP A 130
ARG A 126
ALA A 129
 None
 0.76A 3mbgC-3ngfA:
undetectable		 3mbgC-3ngfA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 11 ASP A 177
GLU A  33
HIS A 201
LEU A 178
ILE A 204
 MN  A 262 (-3.2A)
None
None
None
None
 1.50A 3o94A-3ngfA:
undetectable		 3o94A-3ngfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 11 ASP A 177
GLU A  33
HIS A 201
LEU A 178
ILE A 204
 MN  A 262 (-3.2A)
None
None
None
None
 1.48A 3o94B-3ngfA:
undetectable		 3o94B-3ngfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 11 ASP A 177
GLU A  33
HIS A 201
LEU A 178
ILE A 204
 MN  A 262 (-3.2A)
None
None
None
None
 1.49A 3o94D-3ngfA:
undetectable		 3o94D-3ngfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 HIS A 201
GLU A 142
ASN A  60
 None
MN  A 262 (-2.6A)
None
 0.98A 4bupB-3ngfA:
undetectable		 4bupB-3ngfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 11 GLY A 237
MET A  11
ILE A 204
GLY A 234
PHE A  29
 None
 1.10A 4qoiA-3ngfA:
undetectable
4qoiB-3ngfA:
undetectable		 4qoiA-3ngfA:
20.36
4qoiB-3ngfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 ALA A   5
TRP A 235
VAL A 236
 None
 0.43A 4w9nC-3ngfA:
undetectable		 4w9nC-3ngfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		5 / 10 ALA A  74
ALA A 104
VAL A 139
LEU A 163
VAL A 172
 None
 0.98A 5eb5B-3ngfA:
undetectable		 5eb5B-3ngfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		4 / 5 ALA A 254
TYR A 256
PRO A 213
LEU A 223
 None
 0.97A 5eslA-3ngfA:
undetectable		 5eslA-3ngfA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 HIS A 201
GLU A 142
ASN A  60
 None
MN  A 262 (-2.6A)
None
 0.91A 5wbvA-3ngfA:
undetectable		 5wbvA-3ngfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ngf AP ENDONUCLEASE,
FAMILY 2
(Brucella
abortus) 		3 / 3 HIS A 201
GLU A 142
ASN A  60
 None
MN  A 262 (-2.6A)
None
 0.91A 5wbvB-3ngfA:
undetectable		 5wbvB-3ngfA:
22.11