SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ngj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 7 MET A 197
SER A 156
ALA A 185
ILE A 188
 None
 0.95A 1fxhA-3ngjA:
undetectable
1fxhB-3ngjA:
undetectable		 1fxhA-3ngjA:
19.67
1fxhB-3ngjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 8 MET A 197
SER A 156
ALA A 185
ILE A 188
 None
 0.87A 1gm7A-3ngjA:
undetectable
1gm7B-3ngjA:
undetectable		 1gm7A-3ngjA:
19.67
1gm7B-3ngjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 8 MET A 197
SER A 156
ALA A 185
ILE A 188
 None
 0.91A 1pnlA-3ngjA:
undetectable
1pnlB-3ngjA:
undetectable		 1pnlA-3ngjA:
19.67
1pnlB-3ngjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 7 ILE A  10
ARG A 204
ASP A  92
GLU A  90
 None
None
ZN  A 251 (-3.2A)
None
 1.02A 2qebA-3ngjA:
undetectable		 2qebA-3ngjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 7 ILE A  10
ARG A 204
ASP A  92
GLU A  90
 None
None
ZN  A 251 (-3.2A)
None
 0.99A 2qebB-3ngjA:
undetectable		 2qebB-3ngjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		5 / 12 THR A 161
THR A 157
VAL A  94
ILE A  95
ILE A  97
 None
 1.31A 2yzqA-3ngjA:
undetectable		 2yzqA-3ngjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		5 / 12 VAL A 141
CYH A 145
ALA A 147
ALA A 148
VAL A 100
 None
 0.52A 3fc6C-3ngjA:
undetectable		 3fc6C-3ngjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		5 / 12 ALA A 185
GLY A 187
HIS A 162
SER A 208
ASP A  11
 None
 1.21A 3pfgA-3ngjA:
4.7		 3pfgA-3ngjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		5 / 12 GLY A 158
GLY A 160
THR A 161
ASP A  92
GLY A 186
 None
None
None
ZN  A 251 (-3.2A)
None
 1.01A 3sglA-3ngjA:
undetectable		 3sglA-3ngjA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		5 / 10 VAL A  58
GLY A  57
GLY A  55
LEU A  27
ALA A  31
 None
 1.08A 5vm8B-3ngjA:
undetectable		 5vm8B-3ngjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Entamoeba
histolytica) 		4 / 7 PHE A  66
GLY A 163
ALA A 164
VAL A 182
 None
 0.84A 6dwnB-3ngjA:
undetectable		 6dwnB-3ngjA:
15.06