SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ngo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 9 LEU A 532
ILE A 491
ARG A 172
GLY A 502
ALA A 469
 None
 1.29A 1e7aA-3ngoA:
undetectable		 1e7aA-3ngoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 11 VAL A 241
VAL A 196
TYR A 194
LEU A 254
ILE A 228
 None
 1.39A 1t6zB-3ngoA:
undetectable		 1t6zB-3ngoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 9 SER A 237
LEU A 332
ILE A 285
ALA A 329
LEU A 405
 None
 1.22A 2v0mB-3ngoA:
undetectable		 2v0mB-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 12 SER A 237
LEU A 332
LEU A 354
ILE A 285
ALA A 329
 None
 1.07A 2v0mC-3ngoA:
undetectable		 2v0mC-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 11 SER A 237
LEU A 332
ILE A 285
ALA A 329
LEU A 405
 None
 1.07A 2v0mD-3ngoA:
undetectable		 2v0mD-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		3 / 3 TYR A 422
VAL A 379
THR A 461
 None
 0.53A 2ygnA-3ngoA:
undetectable		 2ygnA-3ngoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		4 / 6 LYS A 178
LEU A 501
LEU A 536
GLU A 537
 None
 0.83A 3h5gB-3ngoA:
undetectable
3h5gC-3ngoA:
undetectable		 3h5gB-3ngoA:
8.47
3h5gC-3ngoA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 12 SER A 413
SER A 417
LEU A 411
THR A 375
ASP A 434
 None
 1.49A 3mbhB-3ngoA:
undetectable		 3mbhB-3ngoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 12 SER A 413
SER A 417
LEU A 411
THR A 375
ASP A 434
 None
 1.48A 3mbhC-3ngoA:
undetectable		 3mbhC-3ngoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 12 SER A 413
SER A 417
LEU A 411
THR A 375
ASP A 434
 None
 1.47A 3mbhD-3ngoA:
undetectable		 3mbhD-3ngoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 11 LEU A 354
VAL A 191
LEU A 536
LEU A 332
LEU A 538
 None
 0.92A 4or0B-3ngoA:
undetectable		 4or0B-3ngoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		5 / 12 ILE A 385
ALA A 357
THR A 496
LEU A 386
LEU A 538
 None
 1.28A 4qynA-3ngoA:
undetectable		 4qynA-3ngoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		3 / 3 TYR A 493
LYS A 495
LYS A 467
 None
 1.29A 5dbyA-3ngoA:
undetectable		 5dbyA-3ngoA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		12 / 12 LEU A 206
TYR A 207
ASN A 325
HIS A 360
PRO A 365
LYS A 371
ASP A 410
ASN A 412
LEU A 414
PHE A 484
ILE A 488
HIS A 529
 None
None
None
None
None
None
MG  A 556 (-2.8A)
MG  A 556 (-3.2A)
None
None
None
MG  A 556 (-4.2A)
 0.32A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		6 / 12 TYR A 207
ASP A 489
LEU A 414
PHE A 484
ILE A 488
HIS A 529
 None
None
None
None
None
MG  A 556 (-4.2A)
 1.25A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		3 / 3 GLU A 240
TRP A 363
ASN A 479
 MG  A 557 (-2.6A)
None
None
 0.16A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		4 / 6 PHE A 189
SER A 186
ALA A 187
HIS A 539
 None
 1.23A 5dzkB-3ngoA:
undetectable
5dzkP-3ngoA:
undetectable		 5dzkB-3ngoA:
19.36
5dzkP-3ngoA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE
(Homo
sapiens) 		4 / 6 PHE A 189
SER A 186
ALA A 187
HIS A 539
 None
 1.24A 5dzkg-3ngoA:
undetectable
5dzku-3ngoA:
undetectable		 5dzkg-3ngoA:
19.36
5dzku-3ngoA:
40.00