SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ngw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 153
VAL A 158
CYH A 113
ALA A 111
 None
 0.82A 1mz9D-3ngwA:
undetectable		 1mz9D-3ngwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		4 / 4 LEU A 153
VAL A 158
CYH A 113
ALA A 111
 None
 0.89A 1mz9E-3ngwA:
undetectable		 1mz9E-3ngwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		3 / 3 LEU A  33
LEU A  23
MET A  22
 None
 0.86A 2itzA-3ngwA:
undetectable		 2itzA-3ngwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 153
PRO A 152
LEU A 156
 None
 0.53A 2po7B-3ngwA:
undetectable		 2po7B-3ngwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 153
PRO A 152
LEU A 156
 None
 0.55A 3hcrA-3ngwA:
undetectable		 3hcrA-3ngwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 138
CYH A  86
LEU A  80
ALA A 134
VAL A  88
 None
 1.16A 4p65C-3ngwA:
undetectable
4p65D-3ngwA:
undetectable
4p65J-3ngwA:
undetectable
4p65L-3ngwA:
undetectable		 4p65C-3ngwA:
16.13
4p65D-3ngwA:
12.90
4p65J-3ngwA:
12.90
4p65L-3ngwA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 137
LEU A 138
ARG A  81
 None
None
CA  A 209 ( 4.7A)
 0.80A 6d8fA-3ngwA:
undetectable		 6d8fA-3ngwA:
14.39