SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ngx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 10 GLY A 251
ILE A 219
GLY A 222
ILE A 223
ALA A 138
 None
 1.05A 1sh9B-3ngxA:
undetectable		 1sh9B-3ngxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
VAL A 153
LEU A 170
MET A 169
ALA A 200
 None
 1.38A 2jj8C-3ngxA:
undetectable		 2jj8C-3ngxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 5 VAL A 198
VAL A 199
THR A 135
THR A 154
 None
 1.24A 3bjwG-3ngxA:
undetectable		 3bjwG-3ngxA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 GLU A  91
ASP A 114
LEU A 262
LEU A  30
GLY A  87
 None
 1.40A 3ce6B-3ngxA:
7.9		 3ce6B-3ngxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		3 / 3 LEU A  94
GLU A  91
ILE A  33
 None
 0.54A 3czhA-3ngxA:
undetectable		 3czhA-3ngxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 5 ASN A  38
ALA A  40
ALA A  41
LYS A  48
 None
 0.73A 3kp2B-3ngxA:
undetectable		 3kp2B-3ngxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 10 PRO A 165
SER A 159
GLY A 163
PRO A 136
ASP A 233
 None
 1.26A 3lsfB-3ngxA:
0.6
3lsfE-3ngxA:
0.0		 3lsfB-3ngxA:
23.13
3lsfE-3ngxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 10 ILE A  76
SER A  68
TYR A  64
ILE A  33
GLU A  62
 None
 1.42A 3u6tA-3ngxA:
undetectable		 3u6tA-3ngxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
THR A 247
THR A 135
GLY A 222
VAL A 162
 None
 1.05A 4c9lA-3ngxA:
undetectable		 4c9lA-3ngxA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
THR A 247
THR A 135
GLY A 222
VAL A 162
 None
 1.07A 4c9oA-3ngxA:
undetectable		 4c9oA-3ngxA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
THR A 247
THR A 135
GLY A 222
VAL A 162
 None
 1.07A 4c9oB-3ngxA:
undetectable		 4c9oB-3ngxA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		3 / 3 PHE A 206
VAL A 243
ILE A 246
 None
 0.60A 4emaA-3ngxA:
undetectable		 4emaA-3ngxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 5 ASN A 224
PRO A 204
GLY A 202
ASP A 220
 None
 1.06A 4n48B-3ngxA:
3.6		 4n48B-3ngxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 GLY A 251
GLY A 252
GLU A   7
ILE A   3
PHE A 236
 None
 1.05A 4zvmA-3ngxA:
5.7
4zvmB-3ngxA:
4.7		 4zvmA-3ngxA:
21.86
4zvmB-3ngxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 6 TYR A  44
TYR A 225
GLY A 254
ASP A 141
 None
 1.22A 5emlA-3ngxA:
2.3		 5emlA-3ngxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 8 GLU A   7
PRO A 248
GLY A 254
PRO A 255
 None
 0.98A 5kf8A-3ngxA:
undetectable		 5kf8A-3ngxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 8 ARG A  50
ILE A 261
ALA A 258
LEU A 262
 None
 0.70A 5te8B-3ngxA:
undetectable		 5te8B-3ngxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		4 / 7 ILE A  57
LEU A  30
MET A  89
LEU A  32
 None
 0.91A 5u4sA-3ngxA:
undetectable		 5u4sA-3ngxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3ngx BIFUNCTIONAL PROTEIN
FOLD
(Thermoplasma
acidophilum) 		5 / 12 PRO A  93
ASP A 114
THR A 135
SER A 159
VAL A 162
 None
 0.63A 6debB-3ngxA:
37.5		 6debB-3ngxA:
12.54